Crawley Lab

Angela M. Crawley profile picture

Contact Information

Angela M. Crawley, Ph.D.

Fax: 613-737-8803
Research Administrative Assistant:
Heidi Hickey,
613-737-8899 x72794

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Selected Publications

    Last 3 years:

    1. Ali H., Caballero R., Iqbal S., Gajnayaka N., Ahmed D., Dong S., Vranjkovic V., Crawley AM., Angel JB., Cassol E., Kumar A. Selective killing of human M1 macrophages by Smac mimetics alone and M2 macrophages by Smac mimetics and caspase inhibition. J. Leuk. Biol. 2021.

    2. Côté, SC., Burke Schinkel, SC., Berthoud TK., Barros PO., Sanchez-Vidales M., Davidson AM., Crawley AM., Angel JB. IL-7 induces sCD127 release and mCD127 downregulation in human CD8+ T cells by distinct yet overlapping mechanisms, both of which are impaired in HIV infection. Eur. J. Immunol., 2020. 50:1537-49.

    3. Li J., Casey JL., Greenwald ZR., Yasseen AS., Dickie M., Feld JJ., Cooper CL., Crawley AM. The 9th Canadian Symposium on Hepatitis C Virus: Advances in HCV research and treatment towards elimination. Can. Liv. J. 2020.

    4. Okwor CIA., Oh JS., Crawley AM., Cooper CL., Lee SH. Expression of inhibitory receptors on T and NK cells defines immunological phenotypes of HCV patients with advanced liver fibrosis. (iScience, 2020. 23(9): 101513 - impact factor: 5.8).

    5. Odai KG., O’Dwyer C., Steenbergen R., Shaw T., Renner T., Ghorbani P., Langlois M-A., Crawley AM., Russell RS., Pezacki J., Tyrrell LD., Fullerton MD. In vitro hepatitis C virus infection and hepatic choline metabolism. Viruses, 12(1). pii: E108, 2020.

    6. Vranjkovic A., Deonarine F., Angel JB., Cooper CL., Crawley AM. Direct-Acting Antiviral Treatment of HCV Infection Does Not Resolve the Dysfunction of Circulating CD8+ T-Cells in Advanced Liver Disease. Frontiers Immunol., 10:1926, 2019.

    7. Doyle MA., Lee T., Singer J., Crawley AM., Klein M., Cooper CL. Evaluation of safety and effectiveness of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (E/C/F/TAF) Switch followed by Ledipasvir Sofosbuvir HCV Therapy in HIV-HCV Co-Infection. Open Forum Infectious Diseases 6(7). pii: ofz318 2019.

    8. Ahmed F., Ibrahim A., Cooper CL., Kumar A., Crawley AM. Chronic Hepatitis C Virus Infection Impairs M1 Macrophage Differentiation and Contributes to CD8 + T-Cell Dysfunction. Cells 2019, 8:374 - Special Issue: Hepatitis C Virus and Host Interactions, by invitation.

    9. Doyle M-A., Mulvihill E., Galanakis C., Crawley AM., Cooper CL. Influence of Ribavirin and the Cirrhotic State on Metabolic Measures in Hepatitis C Direct Acting Antiviral Treatment Recipients. Cells 2019, 8:252 - Special Issue: Hepatitis C Virus and Host Interactions, by invitation.

    All Other Publications

    10. Khan S., Bernier, A., Dapp D., Fortier E., Krajden M., King A., Grebely J., Sagan SM., Cooper CL., Crawley AM. 6th Canadian Symposium on HCV: Delivering a Cure for Hepatitis C Infection: What are the Remaining Gaps? Can. Liver J. 2018, Vol 1(2):94-105.

    11. Khan S., Karges W., Cooper C., Crawley AM. Hepatitis C virus core protein reduces CD8+ T-cell proliferation, perforin production and degranulation but increases STAT5 activation. Immunol. 2018 154(1):156- 65. Angela M. Crawley, Ph.D.

    12. Steele (Leone) A.K., Carrasco-Medina L., Sodora D.L., Crawley AM. Increase in soluble IL-7 receptor levels in plasma is associated with improved therapeutic outcome to IL-7 therapy in SIV-infected ART-treated Rhesus macaques. PlosOne 2017, 12(12): e0188427.

    13. Corsi DJ., Karges W., Thavorn K., Crawley AM., Cooper CL. Influence of female sex on hepatitis C virus infection progression and treatment outcomes. European Journal of Gastroenterology and Hepatology. 2016 28(4): 405-411.

    14. Burke SC., Carrasco-Medina L., Karges W., Cooper CL., Crawley, AM. Generalized liver- and blood derived CD8+ T cell impairment in response to cytokines in chronic hepatitis C virus infection. PlosOne. 2016 11(6): e0157055.

    15. Côté, S., Matte, J., Sad, S., Angel, JB, Crawley AM. Complexed soluble IL-7 receptor α and IL-7 increase IL-7-mediated proliferation and viability of CD8+ T-cells in vitro. Cell. Immunol. 2015 293(2):122-125.

    16. Crawley AM., Vranjkovic A., Faller E., McGuinty M., Burke SC., Cousineau S., MacPherson P., Angel JB. Jak/STAT and PI3K signalling pathways have both common and distinct roles in IL-7 mediated activities in human CD8+ T-cells. J. Leuk. Biol., 2014. 95(1):117-27.

    17. Crawley AM., and Angel JB. 2012. The influence of HIV on CD127 expression and its potential implications for IL-7 therapy. (Invited review article for Semin. Immunol., 24:231-240.

    18. Vranjkovic A., Crawley AM., Patey A., Angel JB. 2012. In vitro HIV Type 1 infection indirectly alters CD127 expression on CD8+ T-cells. AIDS Research and Human Retrovirology. 28:295-298.

    19. Crawley AM., and Angel JB. 2011. Expression of γ-chain cytokine receptors on CD8+ T-cells in HIV infection with a focus on IL-7Rα (CD127). Immunol. Cell. Biol. 90:379-387.

    20. * Vranjkovic A., Crawley AM., Patey A., Angel JB. 2011. IL-7-dependent STAT-5 activation and CD8+ T cell proliferation are impaired in HIV infection. J. Leuk. Biol., 89:499-506. * Note: An editorial introduces this article in its issue: Paiardini M. et al., 2011. J. Leuk Biol. 89:491-3.

    21. O’Connor A., Crawley AM., Angel JB. 2010. Interleukin-7 enhances memory CD8+ T-cell recall responses in health but its activity is impaired in human immunodeficiency virus infection. Immunol., 131(4):525-536.

    22. Crawley AM., Vranjkovic A., Young C., Angel JB. 2010. Interleukin-4 downregulates CD127 expression on human thymocytes and mature CD8+ T-cells. Eur. J. Immunol., 40:1396-1407.

    23. Crawley, AM., Faucher S., Angel JB. 2010. Soluble IL-7Rα (sCD127) inhibits IL-7 activity and is increased in HIV infection. J. Immunol., 184:4679-4787.

    24. Faucher S., Crawley AM., Decker W., Sherring A., Bogdanovic D., Ding T., Bergeron M., Angel JB., Sandstrom P. 2009. Development of a Quantitative Bead Capture Assay for Soluble IL-7 Receptor α in Human Plasma. PLoSONE, 4(8): e6690.

    25. Crawley AM., Katz T., Parato KP., Angel JB. 2009. IL-2 receptor γ chain cytokines differentially regulate human CD8+ CD127+ and CD8+ CD127- T-cell division and susceptibility to apoptosis. Int. Immunol., 21: 29-42. Angela M. Crawley, Ph.D.

    2008 and older
    26. Vranjkovic A.* , Crawley AM. * Gee K., Kumar A., Angel JB. 2007. IL-7 decreases IL-7 receptor- α (CD127) expression and induces shedding of CD127 by human CD8+ T cells. Int. Immunol., 19: 1329-1339. (*contributed equally).

    27. Crawley AM., Mallard B., Wilkie BN. 2005. Genetic selection for high and low immune response in pigs: Effects on immunoglobulin isotype expression. Veterinary Immunology and Immunopathology. 108(1-2):71.

    28. Crawley A., and Wilkie B.N. 2003. Porcine Ig Isotypes: function and molecular characteristics. Vaccine, 21: 2911-2922.

    29. Crawley A., Raymond C., Wilkie B.N. 2003. Control of immunoglobulin isotype production by porcine B cells cultured with cytokines. Vet. Immunol. Immunopathol., 91:141-154.

    PubMed Listings

    For more publications use this PubMed ID link.