Selected Publications

Kolodziejczyk, S.M., Wang, L., Balaszi, K., DeRepentigny, Y., Kothary, R., and Megeney, L.A. (1999). MEF2 activity is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium. Curr. Biol. 9, 1203-1206.  

Fernando, P.S., Kelly, J.F., Balazsi, K., Slack, R.S., and Megeney, L.A. (2002). Caspase 3 activity is required for skeletal muscle differentiation.  Proc.Natl.Acad.Sci.USA. 99. 11025-11030.  

Hierlihy, A, Seale, P.S, Lobe, C.G., Rudnicki, M.A., and Megeney, L.A. (2002).  The post-natal heart contains a myocardial stem cell population.  FEBS Letters. 530, 239-243.  

Fernando, P.S., Brunette, S., and Megeney, L.A. (2005).  Differentiation of neural stem cells depends on endogenous caspase 3 activity.  FASEB J.,19, 1671-1673.  

Abdul-Ghani, M., and Megeney, L.A. (2008).  Rehabilitation of a contract killer:  Caspase 3 directs stem cell differentiation. Cell Stem Cell, 2, 515-516.   

Larsen, B.D., Rampalli, S., Burns, L., Dilworth, F.J. and Megeney, L.A. (2010).  Caspase 3/Caspase activated DNase promote cell differentiation by inducing DNA strand breaks.  Proc.Nat.Acad.Sci.USA. 107, 4230-4235.   

Lee, R.E., Brunette ,S., Puente, L.G. and Megeney, L.A. (2010). Metacaspase Yca1 is required for clearance of insoluble protein aggregates. Proc.Natl.Acad.Sci.USA.107, 13348-13353.  

Abdul-Ghani, M., Dufort, D., Stiles, R., De Repentigny, Y., Kothary, R. and  Megeney, L.A. (2011). Wnt11 promotes cardiomyocyte development by caspase mediated suppression of canonical Wnt signals. Mol.Cell.Biol. 31, 163-178.  

Shrestha, A., Puente, L., Brunette, S., and Megeney, L.A. (2013). The role of Yca1 in Proteostasis. Yca1 Regulates the Composition of the Insoluble Proteome.  J. Proteomics, 81, 24-30.  

Dick, S.A. and Megeney, L.A. (2013).  Cell death proteins: An evolutionary role in cellular adaptation before the advent of apoptosis.  Bioessays, 35, 974-983.  

Putinski, C., Abdul-Ghani, M., Stiles, R., Brunette, S., Dick, S.A., Fernando, P.S., and Megeney, L.A. (2013). Intrinsic-mediated caspase activation is essential for cardiomyocyte hypertrophy. Proc.Natl.Acad.Sci.USA., 110, E4079-4087.  

Dick, S.A. Chang, N.C., Dumont, N.A., Bell, R., Putinski, C., Kawabe, Y., Litchfield, D.W., Rudnicki, M.A. and Megeney, L.A. (2015). Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells. Proc.Natl.Acad.Sci.USA., 112, E5246-5252.  

Al-Khalaf, M., Blake, L., Larsen, B.D., Bell, R.A., Brunette, S., Parks, R.J., Rudnicki, M.A., McKinnon, P.J., Dilworth, F.J. and Megeney, L.A. (2016). Temporal activation of XRCC-1 mediated DNA repair is essential for muscle differentiation. Cell Discovery, 2, 15041.