Dr. Lynn Megeney is a Senior Scientist at the Ottawa Hospital Research Institute, where he also holds academic appointments as a Professor in the Dept. of Medicine (Division of Cardiology) and the Dept. of Cellular and Molecular Medicine at the University of Ottawa. Dr. Megeney was the Holder of the Mach Gaennslen Chair in Cardiac Research from 2005 to 2011. Dr. Megeney has received numerous awards including an International Fellowship form the Chinese Academy of Sciences and the Queen Elizabeth II Diamond Jubilee Medal. Dr. Megeney's laboratory is supported by provincial, national and international funding agencies. In addition to his academic work, Dr. Megeney has been a scientific founder of three biotechnology companies.
Fernando, P.S., Kelly, J.F., Balazsi, K., Slack, R.S., and Megeney, L.A. (2002). Caspase 3 activity is required for skeletal muscle differentiation. Proc.Natl.Acad.Sci.USA. 99. 11025-11030.
Larsen, B.D., Rampalli, S., Burns, L., Dilworth, F.J. and Megeney, L.A. (2010). Caspase 3/Caspase activated DNase promote cell differentiation by inducing DNA strand breaks. Proc.Nat.Acad.Sci.USA. 107, 4230-4235.
Lee, R.E., Brunette ,S., Puente, L.G. and Megeney, L.A. (2010). Metacaspase Yca1 is required for clearance of insoluble protein aggregates. Proc.Natl.Acad.Sci.USA.107, 13348-13353.
Putinski, C., Abdul-Ghani, M., Stiles, R., Brunette, S., Dick, S.A., Fernando, P.S., and Megeney, L.A. (2013). Intrinsic-mediated caspase activation is essential for cardiomyocyte hypertrophy. Proc.Natl.Acad.Sci.USA., 110, E4079-4087.
Dick, S.A. Chang, N.C., Dumont, N.A., Bell, R., Putinski, C., Kawabe, Y., Litchfield, D.W., Rudnicki, M.A. and Megeney, L.A. (2015). Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells.Proc.Natl.Acad.Sci.USA., 112, E5246-5252.
Al-Khalaf, M., Blake, L., Larsen, B.D., Bell, R.A., Brunette, S., Parks, R.J., Rudnicki, M.A., McKinnon, P.J., Dilworth, F.J. and Megeney, L.A. (2016). Temporal activation of XRCC-1 mediated DNA repair is essential for muscle differentiation. Cell Discovery, 2, 15041.
Abdul-Ghani,
M., Suen, C., Jiang, B., Deng, Y., Putinski, C., Brunette, S., Weldrick, J.,
Burgon, P., Fernando, P., Lee, T.T., Flynn, P., Leenen, F., Burgon, P.G.,
Stewart, D.J. and Megeney, L.A. (2017).
Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling
of the heart. Cell Research, 27, 1195-2015.
Shrestha, A., Brunette, S., Stanford, W.L. and
Megeney, L.A. (2019). The metacaspase Yca1 maintains proteostasis
through multiple interactions with the ubiquitin system. Cell Discovery, 5, 6.
Minina,
E.A., Staal, J., Alvarez, V.E., Berges, J.A., Berman-Frank, I., Beyaert, R.,
Bidle, K.D., Bomancin, F., Casanova, M., Cazzulo, J.J., Choi, C.J., Coll, N.S.,
Dolinar, M., Fasel, N., Funk, C., Gallois, P., Gevaert, K., Gutierrez-Beltran,
E., Halfinger, S., Klemencic, M., Koonin, E.V., Krappmann, D., Linusson, A.,
Machado, M.F.M., Madeo, F., Megeney, L.A., Moschou, P.N., Mottram, J.C.,
Nyström, T., Osiewacz, H.D., Overall, C.M., Pandey, K.C., Ruland, J., Salvesen,
G.S., Shi, Y., Smertenko, A., Stael, S., Ståhlberg, J., Suárez, M.F., Thome,
M., Tuominen, H., Van Breusegem, F., van der Hoorn, R.A.L., Zhivotovsky, B., Lam, E., and Bozhkov, P.V.
(2020). Classification and nomenclature of metacaspases
and paracaspases: no more confusion with caspases. Molecular Cell, 77, 927-929.
