Lynn Megeney profile picture

Contact Information

Lynn Megeney, PhD
Tel 613-737-8618

Administrative Assistant
Erin Hicke
Tel 613-737-8899 ext 73841

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Lynn Megeney

Senior Scientist, Regenerative Medicine Program
Ottawa Hospital Research Institute
Professor, Department of Medicine, Department of Cellular and Molecular Medicine
University of Ottawa

Research Interests

Research in the Megeney lab is guided by the hypothesis that apoptotic proteins and pathways evolved core non-death cell function(s). Based on this guiding principle, they are investigating the mechanisms by which metacaspases/caspases direct cell fate/cell differentiation. In addition, they are exploring how these same proteins impact a number of human diseases, including muscular dystrophy, cardiac hypertrophy/heart failure and cancer/tumour formation.

Brief Biography

Dr. Lynn Megeney is a Senior Scientist at the Ottawa Hospital Research Institute, where he also holds academic appointments as a Professor in the Dept. of Medicine (Division of Cardiology) and the Dept. of Cellular and Molecular Medicine at the University of Ottawa. Dr. Megeney was the Holder of the Mach Gaennslen Chair in Cardiac Research from 2005 to 2011. Dr. Megeney has received numerous awards including an International Fellowship form the Chinese Academy of Sciences and the Queen Elizabeth II Diamond Jubilee Medal. Dr. Megeney's laboratory is supported by provincial, national and international funding agencies. In addition to his academic work, Dr. Megeney has been a scientific founder of three biotechnology companies.

Selected Publications

Fernando, P.S., Kelly, J.F., Balazsi, K., Slack, R.S., and Megeney, L.A. (2002). Caspase 3 activity is required for skeletal muscle differentiation. Proc.Natl.Acad.Sci.USA. 99. 11025-11030. 

Larsen, B.D., Rampalli, S., Burns, L., Dilworth, F.J. and Megeney, L.A. (2010). Caspase 3/Caspase activated DNase promote cell differentiation by inducing DNA strand breaks. Proc.Nat.Acad.Sci.USA. 107, 4230-4235. 

Lee, R.E., Brunette ,S., Puente, L.G. and Megeney, L.A. (2010). Metacaspase Yca1 is required for clearance of insoluble protein aggregates. Proc.Natl.Acad.Sci.USA.107, 13348-13353.

Putinski, C., Abdul-Ghani, M., Stiles, R., Brunette, S., Dick, S.A., Fernando, P.S., and Megeney, L.A. (2013). Intrinsic-mediated caspase activation is essential for cardiomyocyte hypertrophy. Proc.Natl.Acad.Sci.USA., 110, E4079-4087.

Dick, S.A. Chang, N.C., Dumont, N.A., Bell, R., Putinski, C., Kawabe, Y., Litchfield, D.W., Rudnicki, M.A. and Megeney, L.A. (2015). Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells.Proc.Natl.Acad.Sci.USA., 112, E5246-5252.

Al-Khalaf, M., Blake, L., Larsen, B.D., Bell, R.A., Brunette, S., Parks, R.J., Rudnicki, M.A., McKinnon, P.J., Dilworth, F.J. and Megeney, L.A. (2016).  Temporal activation of XRCC-1 mediated DNA repair is essential for muscle differentiation. Cell Discovery, 2, 15041.

Abdul-Ghani, M., Suen, C., Jiang, B., Deng, Y., Putinski, C., Brunette, S., Weldrick, J., Burgon, P., Fernando, P., Lee, T.T., Flynn, P., Leenen, F., Burgon, P.G., Stewart, D.J. and Megeney, L.A. (2017).  Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart.  Cell Research, 27, 1195-2015.  

Shrestha, A., Brunette, S., Stanford, W.L. and Megeney, L.A. (2019). The metacaspase Yca1 maintains proteostasis through multiple interactions with the ubiquitin system. Cell Discovery, 5, 6.  

Minina, E.A., Staal, J., Alvarez, V.E., Berges, J.A., Berman-Frank, I., Beyaert, R., Bidle, K.D., Bomancin, F., Casanova, M., Cazzulo, J.J., Choi, C.J., Coll, N.S., Dolinar, M., Fasel, N., Funk, C., Gallois, P., Gevaert, K., Gutierrez-Beltran, E., Halfinger, S., Klemencic, M., Koonin, E.V., Krappmann, D., Linusson, A., Machado, M.F.M., Madeo, F., Megeney, L.A., Moschou, P.N., Mottram, J.C., Nyström, T., Osiewacz, H.D., Overall, C.M., Pandey, K.C., Ruland, J., Salvesen, G.S., Shi, Y., Smertenko, A., Stael, S., Ståhlberg, J., Suárez, M.F., Thome, M., Tuominen, H., Van Breusegem, F., van der Hoorn, R.A.L.,  Zhivotovsky, B., Lam, E., and Bozhkov, P.V. (2020). Classification and nomenclature of metacaspases and paracaspases: no more confusion with caspases.  Molecular Cell, 77, 927-929.

Diseases, conditions and populations of interest

Research and clinical approaches