Sabourin Lab

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Contact Information

Luc Sabourin, PhD

Ottawa Hospital Research Institute
Centre for Cancer Therapeutics
Cancer Centre Building
501 Smyth Road
Box 926
Ottawa, ON. K1H 8L6

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Luc Sabourin

Senior Scientist, Cancer Therapeutics Program
Ottawa Hospital Research Institute
Associate Professor, Cellular and Molecular Medicine
University of Ottawa

Research Interests

Brief Biography

Selected Publications

P. O'Reilly, D. J. Franks, R. Braun and L.A. Sabourin (2005). The Ste20-like kinase SLK is required for cell cycle progression through G2/M. J Biol Chem. 280(51):42383-90.

Z. Chaar, P. O'Reilly, K. Hume and L.A. Sabourin (2006). v-src-Dependent Downregulation of the Ste20-like Kinase SLK by Casein KinaseII. J Biol Chem, 281(38):28193-28199.

S. Wagner, Z.Y. Chaar, K. Roovers, C. J. Storbeck, P. Kolodziej, M. McKay and L.A. Sabourin (2007). FAK/c-src family-dependent activation of the Ste20-like kinase SLK is required for microtubule-dependent focal adhesion turnover and cell migration. PLoS ONE, 3(4): e1868.

K. Roovers, S. Wagner, M. McKay, P. O'Reilly, V. Lo, J. Northey, J. Chmielecki, W.J. Muller, P. Siegel and L. Sabourin (2009). The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility. Oncogene, 28(31):2839-48.

C. Storbeck, K. Hume, S. Wagner, M. McKay, R. Parks, H. Westphal and L.A. Sabourin (2009). The Ldb1 and Ldb2 transcriptional co-factors interact with the Ste20-like kinase SLK and regulate cell migration. Mol Biol Cell, 2009 Oct;20(19):4174-82.

Diseases, conditions and populations of interest

Research and clinical approaches