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Contact Information

Dylan Burger, PhD
613-562-5800 x 8241

2513-451 Smyth Rd.
Ottawa, ON
K1H 7N9

What We Do

Our laboratory seeks to apply our expertise in the area of extracellular vesicle biology to explore mechanisms involved in the pathogenesis of diabetic vascular and renal disease. In particular we are interested in the role of microparticles in these processes. Microparticles are small (0.1-1.0 μm) fragments of membrane that are shed from cells under conditions of stress or injury. We and others have shown that microparticles may serve as biomarkers of underlying disease and that, once shed, microparticles may actually exert biological effects on target cells. 

Current Research Activities

1. The effects of the diabetic microenvironment on circulating microparticle formation and function. 

2. Exploring novel mechanisms of microparticle formation

3. The biology of urinary extracellular vesicles in renal disease. 

4. Microparticles as a diagnostic tool in peritoneal dialysis. 

Selected Publications

Burger D, Thibodeau JF, Holterman CE, Burns KD, Touyz RM, Kennedy CRJ (2014) “Urinary podocyte microparticles identify pre-albuminuric diabetic glomerular injury”. J Am Soc Nephrol

Burger D, Schock S, Thompson CS, Montezano AC, Hakim AM, Touyz RM (2013) “Microparticles: Biomarkers and Beyond”. Clin Sci 124(7) 423-441

Burger D*, Kwart DG*, Montezano AC, Read NC, Kennedy CRJ, Thompson CS, Touyz RM (2012) “Microparticles Induce Cell Cycle Arrest Through Redox-Sensitive Processes in Endothelial Cells: Implications in Vascular Senescence”. J Am Heart Assoc 1:e001842.

Burger D, Touyz RM (2012) “Cellular Biomarkers of Endothelial Health: Microparticles, Endothelial Progenitor Cells, and Circulating Endothelial Cells”. J Am Soc Hypertens 6(2) 85-99

Burger D, Montezano AC, Nishigaki N, Touyz RM (2011) “Endothelial Microparticle Formation by Ang II is Mediated by AT1R/NADPH oxidase/Rho kinase Pathways Targeted to Lipid Rafts”. Arterioscler Thromb Vasc Biol 31(8) 1898-1907

Meet the Burger Lab