Lynn Megeney profile picture

Contact Information

Lynn Megeney, PhD
Tel 613-737-8618

Administrative Assistant
Erin Hicke
Tel 613-737-8899 ext 73841

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What We Do

Selected Publications

Fernando, P.S., Kelly, J.F., Balazsi, K., Slack, R.S., and Megeney, L.A. (2002). Caspase 3 activity is required for skeletal muscle differentiation. Proc.Natl.Acad.Sci.USA. 99. 11025-11030. 

Larsen, B.D., Rampalli, S., Burns, L., Dilworth, F.J. and Megeney, L.A. (2010). Caspase 3/Caspase activated DNase promote cell differentiation by inducing DNA strand breaks. Proc.Nat.Acad.Sci.USA. 107, 4230-4235. 

Lee, R.E., Brunette ,S., Puente, L.G. and Megeney, L.A. (2010). Metacaspase Yca1 is required for clearance of insoluble protein aggregates. Proc.Natl.Acad.Sci.USA.107, 13348-13353.

Putinski, C., Abdul-Ghani, M., Stiles, R., Brunette, S., Dick, S.A., Fernando, P.S., and Megeney, L.A. (2013). Intrinsic-mediated caspase activation is essential for cardiomyocyte hypertrophy. Proc.Natl.Acad.Sci.USA., 110, E4079-4087.

Dick, S.A. Chang, N.C., Dumont, N.A., Bell, R., Putinski, C., Kawabe, Y., Litchfield, D.W., Rudnicki, M.A. and Megeney, L.A. (2015). Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells.Proc.Natl.Acad.Sci.USA., 112, E5246-5252.

Al-Khalaf, M., Blake, L., Larsen, B.D., Bell, R.A., Brunette, S., Parks, R.J., Rudnicki, M.A., McKinnon, P.J., Dilworth, F.J. and Megeney, L.A. (2016).  Temporal activation of XRCC-1 mediated DNA repair is essential for muscle differentiation. Cell Discovery, 2, 15041.

Abdul-Ghani, M., Suen, C., Jiang, B., Deng, Y., Putinski, C., Brunette, S., Weldrick, J., Burgon, P., Fernando, P., Lee, T.T., Flynn, P., Leenen, F., Burgon, P.G., Stewart, D.J. and Megeney, L.A. (2017).  Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart.  Cell Research, 27, 1195-2015.  

Shrestha, A., Brunette, S., Stanford, W.L. and Megeney, L.A. (2019). The metacaspase Yca1 maintains proteostasis through multiple interactions with the ubiquitin system. Cell Discovery, 5, 6.  

Minina, E.A., Staal, J., Alvarez, V.E., Berges, J.A., Berman-Frank, I., Beyaert, R., Bidle, K.D., Bomancin, F., Casanova, M., Cazzulo, J.J., Choi, C.J., Coll, N.S., Dolinar, M., Fasel, N., Funk, C., Gallois, P., Gevaert, K., Gutierrez-Beltran, E., Halfinger, S., Klemencic, M., Koonin, E.V., Krappmann, D., Linusson, A., Machado, M.F.M., Madeo, F., Megeney, L.A., Moschou, P.N., Mottram, J.C., Nyström, T., Osiewacz, H.D., Overall, C.M., Pandey, K.C., Ruland, J., Salvesen, G.S., Shi, Y., Smertenko, A., Stael, S., Ståhlberg, J., Suárez, M.F., Thome, M., Tuominen, H., Van Breusegem, F., van der Hoorn, R.A.L.,  Zhivotovsky, B., Lam, E., and Bozhkov, P.V. (2020). Classification and nomenclature of metacaspases and paracaspases: no more confusion with caspases.  Molecular Cell, 77, 927-929.

Meet the Megeney Lab