Researchers at The Ottawa Hospital are playing a lead role in 13 new projects awarded more than $7 million from the Canadian Institutes of Health Research (CIHR).

These projects will advance science and improve health in areas such as tuberculosis, cancer, thrombosis, environmental sustainability, surgery, stroke, atrial fibrillation, lung injury, arthritis and skin infections.

“These research projects will help us provide the best care possible for our patients and community, while advancing science and improving health on a global scale,” said Dr. Duncan Stewart.

The Ottawa Hospital Research Institute had a success rate of 30% percent in this competition compared to the national average of 22% percent and our hospital currently ranks among the top five in the country for CIHR funding.

The new grants include:

The Taima TB wastewater study - $3,037,050

• Principal Investigator(s): Alvarez, Gonzalo G; Sun, Jim; Delatolla, Robert; Allen, Jean M
• Co-Investigator(s): Ward, Leonor; Desjardins, Marc; Graber, Tyson; Mallick, Ranjeeta; Aaron, Shawn D; Mulpuru, Sunita; Brophy, Jason C; Pease, Christopher; Cameron, D.William

Overcoming barriers to effective cancer immunotherapy with an engineered virus based therapeutic -$100,000

• Principal Investigator(s): Bell, John C
• Co-Investigator(s): Boulton, Stephen; Crupi, Mathieu J; Ardolino, Michele

Colchicine to Quench the Inflammatory Response after Deep Vein Thrombosis:  A Pilot Randomized Controlled Trial - CONQUER-DVT Pilot Trial - $374,850

• Principal Investigator(s): Carrier, Marc; Siegal, Deborah M; Le Gal, Grégoire; Kahn, Susan R; Shivakumar, Sudeep P
• Co-Investigator(s): Duffett, Lisa; Cervi, Andrea L; Abdulrehman, Jameel; Mai, Vicky; Leonard, Blair J; Mallick, Ranjeeta; Chan, Noel; Lazo-Langner, Alejandro; Munro, Camille; Douketis, James D; Delluc, Aurelien; Potere, Nicola; Ramsay, Timothy O

COBRRA trial: Comparison of Bleeding Risk between Rivaroxaban and Apixaban for the treatment of acute venous thromboembolism - $634,951

• Principal Investigator(s): Castellucci, Lana
• Co-Investigator(s): Kahn, Susan R; Kovacs, Michael J; Thavorn, Kednapa; Ramsay, Timothy O; Roberge, Guillaume; Grant, Alyssa; Mai, Vicky; de Wit, Kerstin; Le Gal, Grégoire; Wan, Tony; Rodger, Marc A; Douketis, James D; Ostrowski, Margaret

Environmental Sustainability in Hospitals: A Series of Scoping Reviews -$100,000

• Principal Investigator(s): Kanji, Salmaan; Tricco, Andrea C; Moloo, Husein; Hutton, Brian
• Co-Investigator(s): Lunny, Carole A; Kuo, Alex; Sajwani, Shellyza; Kyeremanteng, Kwadwo; Thabet, Pierre; Forster, Alan J

Non-hOme Transition rIsk Following surgerY (NOTIFY) study - $378,676

• Principal Investigator(s): McIsaac, Daniel I; Kidd, Gurlavine D; Wijeysundera, Duminda N; Flexman, Alana M; Garland, Allan; Hallet, Julie; Wong, Camilla L; Kobewka, Daniel M; Van Walraven, Carl
• Co-Investigator(s): Khadaroo, Rachel; Hladkowicz, Emily; Lee, Susan M; Lalu, Manoj M; Mbadjeu Hondjeu, Arnaud Romeo; Ladha, Karim; Aucoin, Sylvie D; Boet, Sylvain; Bryson, Gregory L; Carrier, François M; Chesney, Tyler; Forster, Alan J; Abdellatif, Soha; Alkadri, Jamal; Ma, Grace; Gagné, Sylvain; Grudzinski, Alexa L; Holroyd-Leduc, Jayna M; Huang, Allen R; Jerath, Angela; Moloo, Husein; Power, Barbara E; McIsaac, Sarah; Auer, Rebecca Ann C; Beattie, William S; Mayson, Kelly V; Talarico, Robert F; Huang, Shirley; Reich, Krista; Martel, Guillaume; Lavallée, Luke T; Ke, Xue Chen; Beckerleg, Weiwei; Taljaard, Monica; Sutherland, Jason M; Tanuseputro, Peter; Backman, Chantal; Breau, Rodney H
• ET AL.

PREPARE for Cancer Surgery Trial: multimodal PReoperative Exercise to decrease PostoperAtive disability, cancer RecurrencE and mortality in older people with frailty - $100,000

• Principal Investigator(s): McIsaac, Daniel I; Khadaroo, Rachel; Gillis, Chelsia A; Muscedere, John; Taljaard, Monica; Kidd, Gurlavine D; Fergusson, Dean A; Eskander, Antoine
• Co-Investigator(s): Ladha, Karim; Huang, Allen R; Bryson, Gregory L; Serrano, Pablo E; Scheede-Bergdahl, Celena; Saha, Tarit; Nantel, Julie; Nagpal, Sudhir; Lavallée, Luke T; Lalu, Manoj M; Hladkowicz, Emily; Gagné, Sylvain; Forster, Alan J; Boet, Sylvain; Power, Barbara E; Moloo, Husein; Wijeysundera, Duminda N; Van Walraven, Carl; Lee, Susan M; Holroyd-Leduc, Jayna M; Breau, Rodney H; Nelson, Gregg; Ouyang, Yongdong; Vickers, Michael M; Chesney, Tyler; Johnson, Ana; Ong, Michael; Thavorn, Kednapa

Feasibility of Advance Consent for ParticipaTION in Acute Stroke Trials (ACTION) - $126,225

• Principal Investigator(s): Shamy, Michel C; Dowlatshahi, Dariush
• Co-Investigator(s): Lindsay, Mary Patrice; Hill, Michael D; Swartz, Richard; Fahed, Robert; Nicholls, Stuart G; Gocan, Sophia; Shepherd, Victoria; Poppe, Alexandre Y; Perry, Jeffrey J; Menon, Bijoy K; Brehaut, Jamie C

A randomized trial of anti-arrhythmic agents to improve management of emergency department patients with acute atrial fibrillation - $302,176

• Principal Investigator(s): Stiell, Ian G
• Co-Investigator(s): Macle, Laurent; Perry, Jeffrey J; Nicholls, Stuart G; Eagles, Debra; Yadav, Krishan; Parkash, Ratika; Taljaard, Monica; Mercier, Eric; Morris, Judy M; Vadeboncoeur, Alain; Archambault, Patrick; Birnie, David H; McRae, Andrew D; Scheuermeyer, Frank; Hohl, Corinne M; Campbell, Samuel G; Sivilotti, Marco L; Emond, Marcel; Cournoyer, Alexis; Thavorn, Kednapa

Therapeutic potential of stem cells in lung injury- $971,550

• Principal Investigator(s): Thébaud, Bernard

Reducing inequitable differences in health outcomes in the treatment of arthritis -$416,924

• Principal Investigator(s): Tugwell, Peter S; Welch, Vivian A
• Co-Investigator(s): Barber, Claire E; Hazlewood, Glen S; Toupin April, Karine; Tomlinson, Eve; Shea, Beverley J; Maxwell, Lara; Magwood, Olivia; Li, Linda C; Lee, Alex Young Soo; Dewidar, Omar K; Darzi, Andrea; Barnabe, Cheryl C; Ali, Shehzad; Petkovic, Jennifer

EPIphANy (Evaluation of Pharmacological Interactions with Anticoagulants in caNcer patients) program - prostate cancer cohort - $164,476

• Principal Investigator(s): Wang, Tzu-Fei; Sood, Manish M
• Co-Investigator(s): Carrier, Marc; Bossé, Dominick; Ravani, Pietro; Hawken, Steven; Tangri, Navdeep; Tanuseputro, Peter

High-dose cephalexin for cellulitis (HI-DOCC): a randomized controlled trial - $382,500

• Principal Investigator(s): Yadav, Krishan; Stiell, Ian G; Perry, Jeffrey J; Emond, Marcel; Taljaard, Monica; Eagles, Debra
• Co-Investigator(s): Borgundvaag, Bjug; Campbell, Samuel G; de Wit, Kerstin; Suh, Kathryn N; McRae, Andrew D; Mercier, Eric; Yan, Justin; Ohle, Robert; Nicholls, Stuart G; Corrales-Medina, Vicente F; Hohl, Corinne M; Savage, David; Daoust, Raoul; MacFadden, Derek R; Thavorn, Kednapa; Zheng, Bo; Blanchard, Pierre-Gilles

STOPNET - A Randomized Study of Cessation of Somatostatin Analogues after Peptide Receptor Radionuclide Therapy in Mid and Hind Gut Neuroendocrine Tumours - $260,101

• Principal Investigator(s): Loree, Jonathan M; O'Callaghan, Christopher J
• Co-Investigator(s): Asmis, Timothy R; Barker, Daniel; Burge, matthew; Goodwin, Rachel A; Laidley, David; Little, Marie-Terese; Rayson, Daniel; Singh, Simron; Solar Vasconcelos, Joao Paulo; Tu, Dongsheng; Wyld, David
• Note: this grant is administered at the University of British Columbia

These projects are supported by core resources for research at The Ottawa Hospital, such as the Ottawa Methods Centre.

The Ottawa Hospital is a leading academic health, research and learning hospital proudly affiliated with the University of Ottawa and supported by The Ottawa Hospital Foundation.