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Contact Information

Brian Hutton, MSc, PhD
613-737-8899 ext 73842

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Brian Hutton

Senior Scientist, Methodological & Implementation Research
Ottawa Hospital Research Institute
Associate Professor, School of Epidemiology, Public Health and Preventive Medicine
University of Ottawa
Adjunct Scientist
Royal Ottawa Mental Health Center

Research Interests

Systematic reviews and meta-analysis; network meta-analysis (and other methods for indirect comparisons of interventions); technology assessment; rapid reviews; scoping reviews; overviews; oncology; mental health and addiction; real-world data.

Brief Biography

Dr. Hutton is a Senior Scientist with the OHRI's Clinical Epidemiology Program, an Associate Professor within the University of Ottawa's Faculty of Epidemiology and Community Medicine and Adjunct Scientist with the Royal Ottawa Mental Health Center. His primary research interests currently lie in the realm of network meta-analysis, systematic reviews and other forms of evidence synthesis. He directed the Knowledge Synthesis Group from 2015-22, and previously led CIHR-funded network meta-analysis research projects and other forms of knowledge synthesis (including systematic reviews, rapid reviews and scoping reviews) for the Drug Safety and Effectiveness Network, with topics including treatments for latent tuberculosis, the influence of industry relationships on prescribing, the incidence of preventable adverse drug reactions, and best evidence interventions for management of chronic pain, amongst others. Dr. Hutton was awarded a 5-year CIHR New Investigator Award and led the development of the extension of the PRISMA statement for reporting of network meta-analyses. Dr. Hutton also contributes time to the Ottawa Regional Cancer Center in the role of methodologist. His past and current research includes works in the realms of oncology, transfusion medicine, infectious diseases, mental health, addiction medicine and several other clinical fields. Most recently Dr. Hutton has undertaken research related the evaluation of interventions for opioid use disorder, the health effects of cannabis consumption and artificial intelligence applications in knowledge synthesis. He holds an H-index of 62, an I10-index of 186 and has been awarded many grants as PI, co-PI and co-I (see Funding page for details).

Selected Publications

Access to many of the listed publications can be sought from

Evaluating comparative effectiveness of psychosocial interventions adjunctive to opioid agonist therapy for opioid use disorder: A systematic review with network meta-analyses. Rice D, Corace K, Wolfe D, Esmaeilisaraji L, Michaud A, Grima A, Austin B, Douma R, Barbeau P, Butler C, Willows M, Poulin PA, Sproule BA, Porath A, Garber G, Taha S, Garner G, Skidmore B, Moher D, Thavorn K, Hutton B. PLoS One. 2020 Dec 28;15(12):e0244401. doi: 10.1371/journal.pone.0244401.

An Evaluation of Distiller SR's Machine Learning-based Prioritization Tool for Title/Abstract Screening–Impact on Reviewer-Relevant Outcomes. Hamel C, Kelly SE Thavorn K, Rice D, Wells G, Hutton B. BMC Medical Research Methodology. 2020 Oct 15;20(1):256.

Optimising weight-loss interventions in cancer patients – A systematic review and network meta-analysis. Levasseur N, Cheng W, Mazzarello S, Clemons M, Vandermeer L, Jones L, Joy A, Barbeau P, Wolfe D, Ahmadzai N, Hersi M, Stober C, Shorr R, Hilton J, Hutton B. PloS One 16(2): e0245794.

A systematic review and network meta-analysis of existing pharmacologic therapies in patients with idiopathic sudden sensorineural hearing loss. Ahmadzai N, Cheng W, Kilty S, Esmaeilisaraji L, Wolfe D, Bonaparte J, Schramm D, Fitzpatrick E, Lin V, Moher D, Hutton B. PLOS One 14(9): 2019.

The pharmacological and non-pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents: A systematic review with network meta-analyses of randomised trials. Catalá-López F, Hutton B, Núñez-Beltrán A, Page MJ, Ridao M, Macías Saint-Gerons D, Catalá MA, Tabarés-Seisdedos R, Moher D. PLoS One. 2017 Jul 12;12(7):e0180355. doi: 10.1371/journal.pone.0180355. eCollection 2017.

The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Hutton B, Salanti G, Caldwell DM, Chaimani A, Schmid CH, Cameron C, Ioannidis JP, Straus S, Thorlund K, Jansen JP, Mulrow C, Catalá-López F, Gøtzsche PC, Dickersin K, Boutron I, Altman DG, Moher D. Ann Intern Med. 2015 Jun 2;162(11):777-84.

Efficacy and completion rates of rifapentine and isoniazid (3HP) compared to other treatment regimens for latent tuberculosis infection: a systematic review with network meta-analyses. Pease C, Hutton B, Yazdi F, Wolfe D, Hamel C, Quach P, Skidmore B, Moher D, Alvarez GG. BMC Infect Dis. 2017 Apr 11;17(1):265.

Network meta-analysis for comparing treatment effects of multiple interventions: an introduction. Catalá-López F, Tobías A, Cameron C, Moher D, Hutton B. Rheumatol International. 2014 Apr 2

The quality of reporting methods and results in network meta-analyses: an overview of reviews and suggestions for improvement. Hutton B, Salanti G, Chaimani A, Caldwell DM, Schmid C, Thorlund K, Mills E, Catalá-López F, Turner L, Altman DG, Moher D. PLoS One. 2014 Mar 26;9(3):e92508. doi: 10.1371/journal.pone.0092508. eCollection 2014.

Diseases, conditions and populations of interest

Research and clinical approaches