Kothary Lab

Rashmi Kothary profile picture

Contact Information

Rashmi Kothary, Ph.D.

Lab Tel: 613-739-6634

Heidi Hickey
Research Administrative Assistant
Tel: 613-737-8899 x72794
Email: hhickey@ohri.ca

ORCID logo https://orcid.org/0000-0002-9239-7310

Rashmi Kothary

Senior Scientist, Regenerative Medicine Program
Ottawa Hospital Research Institute
Deputy Scientific Director
Ottawa Hospital Research Institute
Professor, Medicine
University of Ottawa
Professor, Cellular and Molecular Medicine
University of Ottawa

Research Interests

Our laboratory is interested in understanding the mechanisms which maintain/alter muscle and nervous system integrity. In parallel, we are assessing ways to alleviate the pathology of neuromuscular diseases.

Brief Biography

Dr. Kothary is the Deputy Scientific Director and Senior Scientist at the Ottawa Hospital Research Institute (OHRI). He received a Ph.D. in Biochemistry from the University of British Columbia and pursued postdoctoral research in the laboratories of Dr. Janet Rossant at the Mount Sinai Hospital Research Institute in Toronto and Dr. Azim Surani in Cambridge, U.K. It was during these formative years that Dr. Kothary developed his interests in the use of transgenic mice to model disease pathology. In 1990, he returned to Canada to begin his independent research career at the Institut du cancer de Montréal. In 1998, Dr. Kothary joined the OHRI. He held the University Health Research Chair in Neuromuscular Disorders and is a Professor at the University of Ottawa. In 1999, he and Dr. Bernard Jasmin created as co-Directors, the University of Ottawa Centre for Neuromuscular Disease. His current research focuses on studying the fundamental role of a cytoskeletal linker protein important for intracellular trafficking, investigating extrinsic and intrinsic factors important for oligodendrocyte mediated myelination and remyelination of the CNS, and understanding Spinal Muscular Atrophy pathogenesis and identifying novel therapeutics for this devastating children’s disease. He is on the scientific advisory board for MDA and CureSMA.

Selected Publications

Eshraghi M, McFall E, Gibeault S, Kothary R. (2016) Effect of genetic background on the phenotype of the Smn2B/- mouse model of spinal muscular atrophy. Hum Mol Genet.2016 Aug 18. pii: ddw278. [Epub ahead of print].

Deguise, M.O., Justin G. Boyer, J.G., McFall, E., Yazdani, A., De Repentigny, Y., Kothary, R. (2016) Differential induction of muscle atrophy pathways in two mouse models of spinal muscular atrophy. Scientific Reports. 6:28846.

Michalski, J-P., and Kothary, R. (2015). Oligodendrocytes in a nutshell. Frontiers in Cellular Neuroscience 9: 340.

Murray, L.M., Beauvais, A., Gibeault, S., Courtney, N.L., and Kothary, R. (2015). Transcriptional profiling of differentially vulnerable motor neurons at pre-symptomatic stage in the Smn (2b/-) mouse model of spinal muscular atrophy. Acta Neuropathol. Comm. 3: 55. 

Ferrier, A., De Repentigny, Y., Lynch-Godrei, A., Gibeault, S., Eid, W., Kuo, D., Zha, X., and Kothary, R. (2015). Disruption in the autophagic process underlies the sensory neuropathy in dystonia musculorum mice. Autophagy 11: 1025-1036.

Diseases, conditions and populations of interest

Research and clinical approaches