Ottawa Methods Centre (OMC)


The Ottawa Methods Centre has provided support for all of the clinical projects that were funded at the Ottawa Hospital Research Institute. Explore our recent news to learn more about how these projects will advance science and improve health care for Canadians.

Patients and clinical trial experts key to upcoming made-in-Canada CAR-T clinical trial


Researchers at The Ottawa Hospital and the University of Ottawa are known around the world for their expertise in designing and leading clinical trials, and they're now applying this knowledge to create a made-in-Canada approach for CAR-T cell clinical trials. CAR-T therapy uses a patient's own genetically engineered immune cells to attack their cancer.

Research could help people with cancer avoid life-threatening blood clots


In September 2018, Harold Black had trouble catching his breath while singing in his church choir. It turned out he had a life-threatening blood clot – a condition that is more common in people with cancer, like Harold. Today, people with cancer have a much better chance of avoiding blood clots, thanks to research at The Ottawa Hospital.

Researchers use leading-edge technology to study teamwork and communication in the operating room


Researchers at The Ottawa Hospital and the University of Ottawa are studying whether improving teamwork and communication among operating room staff can make surgery safer for patients. Studies suggest that over half of surgery complications can be linked to problems with these “soft skills” during operations.

How long do people need to be monitored after fainting?


For the first time, physicians in the Emergency Department (ED) have evidence-based recommendations on how best to catch the life-threatening conditions that make some people faint. New research published in Circulation suggests that low-risk patients can be safely sent home by a physician after spending two hours in the ED, and medium and high-risk patients can be sent home after six hours if no danger signals are detected.

Drug dramatically reduces risk of dangerous blood clots in cancer patients


A Canadian clinical trial published in the New England Journal of Medicine provides the first approach for safely preventing blood clots (or venous thromboembolism) in people with cancer. About half of people newly diagnosed with a solid cancer could be candidates for the strategy, which involves a low dose of a direct oral anticoagulant called apixaban.

High dose folic acid does not prevent preeclampsia in high-risk women


Taking high doses of folic acid throughout pregnancy does not prevent preeclampsia in high-risk women, according to a large international clinical trial published in The BMJ. This refutes the findings of previous observational studies and is expected to change practice worldwide.

Radioactive seeds for breast cancer surgery: better for patients and the health-care system


Tiny breast tumours are difficult for surgeons to find and remove during surgery. For years, the only way to do it was to insert a wire (known as a harpoon) into the breast to mark the tumour during pre-surgical imaging. But the wire was uncomfortable and sometimes shifted. Today, a tiny radioactive seed is implanted instead, making it easier for surgeons to find and fully remove the cancer.

$1.7 million to advance research on colon cancer, brain development, kidney disease and severe fluid loss


Four research groups at The Ottawa Hospital, affiliated with the University of Ottawa, have been awarded $1.7 million in the most recent project grant competition from the Canadian Institutes of Health Research (CIHR). Their projects will advance science and improve health in areas such as severe fluid loss, colon cancer screening, brain development and kidney disease.

Urologists reduce unnecessary prostate cancer surgery in Eastern Ontario


A growing number of patients in Eastern Ontario are being saved from unnecessary prostate cancer surgeries, according to a study led by Dr. Luke Lavallée and Dr. Luke Witherspoon published in CMAJ Open. While prostate cancer is the most common cancer in men, in the past it has been over-diagnosed and overtreated. Surgery is a good treatment option for some prostate cancers, but may not be needed for men with low-risk cancer.

Researchers push for better patient engagement


Research improves patient care, and a growing movement aims to engage and involve patients in the research process from start to finish. However, little is known about what meaningful patient engagement in research looks like. To find out, Dr. Dean Fergusson and his team looked at 2,777 trials published between 2011 and 2016. They found only 23 of these studies reported some form of patient engagement, showing much work needs to be done to promote true patient partnership in research.

Dr. Dean Fergusson chosen as President-Elect of international clinical trial society


Dr. Dean Fergusson was elected President-Elect of the Society for Clinical Trials. This organization works internationally to advance human health by advocating for the use of clinical trials, leading the development and dissemination of optimal methods and practices, and educating and developing clinical trial professionals. Its membership includes behavioral scientists, bioethicists, biostatisticians, clinical coordinators, computer scientists, data managers, epidemiologists, nurses, pharmacologists and physicians. “With the promise of innovative therapies coupled with innovative clinical trial designs, we have a tremendous opportunity to advance the science and practice of trials through mutual

Exercise, eye exams help prevent falls in older people


Falls in older individuals can reduce quality of life and cause serious injury. Dr. Kednapa Thavorn was part of a group of researchers who published a meta-analysis in JAMA that identified the best ways to prevent falls in older people. After analyzi

$870,000 to help develop stem cell treatments for septic shock, glaucoma, lung injury and muscle degeneration


Researchers from The Ottawa Hospital, CHEO and the University of Ottawa are bringing discoveries made in the lab closer to human trials and therapies, thanks to five new peer-reviewed research grants from the Ontario Institute for Regenerative Medi

$5.5 million to help save lives when the heart stops and standardize care for rapid heartbeat


Two national projects led by Ottawa emergency medicine researchers received a total of $5.5 million from the Cardiac Arrhythmia Network of Canada (CANet) and matching funders. Dr. Christian Vaillancourt’s team* aims to help 9-1-1 communication offi

Is that diagnostic test accurate? Made-in-Ottawa guideline expected to change research around the world


In a world of constantly conflicting medical studies, systematic reviews have become an essential tool for health-care decision making. In 2009, Dr. David Moher and his colleagues created the original PRISMA guidelines to help make these reviews more useful for doctors and policy makers by ensuring that key details were included. Now Dr. Matthew McInnes has led the development of an adaptation of the guidelines specifically for systematic reviews that look at the accuracy of diagnostic tests. These tests are done to confirm whether an individual has a disease or condition, and include imaging and laboratory tests. The 24-member PRISMA-DTA group refined PRISMA for diagnostic test accuracy by modifying 17 items, omitting two items and adding two new items. The new guidelines, published in JAMA, are expected to improve transparency of these systematic reviews and allow for more informed decision making regarding the use of diagnostic tests. Similar made-in-Ottawa guidelines have been en

Screening for sepsis: new study warns clinicians against quick bedside tool


When identifying patients at risk of death from sepsis, clinicians are better off using the systemic inflammatory response syndrome (SIRS) criteria than the quick Sequential Organ Failure Assessment (qSOFA) score, according to the largest systemati

The Ottawa Hospital awarded $12.7M for research, double the national CIHR success rate


Sixteen research groups at The Ottawa Hospital, affiliated with the University of Ottawa, have been awarded $12.7 million in the most recent project grant competition from the Canadian Institutes of Health Research (CIHR). This represents a success r

Newborn sepsis: Could routinely collected blood spots help with early detection?


Sepsis is a major cause of death and illness in newborns worldwide. It occurs when an infection spreads throughout the body and enters the bloodstream. A study led by Drs. Deshayne Fell, Steven Hawken, and Kumanan Wilson found that blood spots rout

Finding better ways to bring health research to life: World-leading Centre for Implementation Research opens at The Ottawa Hospital


Researchers regularly make discoveries that have the potential to improve patient care and quality of life. However, getting those findings adopted by health-care systems can be a challenge. Researchers at The Ottawa Hospital are already world l

Researchers to test patient-centered approach to Parkinson’s care


Dr. Tiago Mestre has received a $197,000 New Investigator Award from the Physicians’ Services Incorporated Foundation to test a new model of care for people living with Parkinson’s disease. This project, called the Integrated Parkinson’s Care Network

Three Ottawa researchers among “world’s most influential scientific minds”


Drs. Mark Freedman, Jeremy Grimshaw and David Moher were recently ranked among the world’s top 3,300 “most influential scientific minds”. This puts them in the top 0.05 percent of the estimated 7.8 million full-time researchers worldwide. The list,

Blood transfusions in heart surgery: global study sets new standard


A study co-led by Dr. Dean Fergusson found that using lower hemoglobin thresholds to transfuse red blood cells during and after heart surgery is just as safe as using traditional thresholds. Hemoglobin is a protein that delivers oxygen to the body’

Predatory journals: researchers propose solutions to stop the “corruption of science”


The team of researchers behind a landmark study on predatory journals has now outlined the first concrete steps that stakeholders can take to combat the growing influence of these journals. Their pioneering work is published in Nature Human Behavior.

Stem cells for septic shock: world-first trial establishes safety, sets stage for larger trial


Stem cells are usually thought of as the building blocks of the body – able to give rise to all our cells and organs. But Dr. Lauralyn McIntyre, Dr. Duncan Stewart, Dr. Dean Fergusson and their colleagues are testing the idea that certain stem cells may also be able to help control the body’s immune system to reduce injury and promote healing, while improving its ability to fight infection. They recently published the results of the world’s first clinical trial of mesenchymal stem cell therapy for septic shock, a life-threatening condition that can occur when an infection spreads throughout the body. The trial involved thirty patients, nine of whom were treated with up to 250 million mesenchymal stem cells. No serious adverse events occurred. A randomized, multi-site trial is expected to start next year, with the power to evaluate benefits as well as risks. Charles Berniqué, a 73-year-old grandfather from Hawkesbury, Ontario, recently survived a deadly infection requiring prolon

Does this liver surgery patient need a blood transfusion? New tool can help doctors decide


Health care providers now have a new tool to help decide whether a liver surgery patient needs a blood transfusion, thanks to a study led by Drs. Guillaume Martel and Dean Fergusson. Liver surgery often involves major bleeding, and about one in four patients will receive a transfusion. While transfusions can be lifesaving, they also come with small risks such as infections, allergic reactions, cardiovascular effects and possibly worse cancer results after surgery. To develop the tool, a multidisciplinary panel of experts performed a systematic review that looked at 468 scenarios before, during and after liver surgery. 47.4% of the situations were appropriate for transfusion, 28.2% were inappropriate and 24.4% were uncertain. The resulting tool published in Annals of Surgeryuses a number of patient factors to calculate whether a transfusion is appropriate, inappropriate or uncertain. This tool is unique because it can be applied to transfusions given both during and after liver surger

New members of the Royal Society of Canada join the ranks of academic trailblazers


Dr. Ian Graham has been elected a fellow of the Royal Society of Canada (RSC), the highest academic accolade for scholars, artists and scientists in Canada. Fellowship includes sitting on panels to advise policy makers on decisions of great impact.

Making research results available to improve health: The Ottawa Hospital and the University of Ottawa take the lead


“Participating in research requires a lot of time and trust,” said Becky Hollingsworth, who participated in an asthma research study at The Ottawa Hospital. “It is good to see that researchers at The Ottawa Hospital are doing everything they can to

Predatory journals a global problem: Investigation in Nature reveals high income countries not immune


A massive investigation published in Nature shows that contrary to popular belief, a majority of papers in suspected biomedical predatory journals (57 percent) are from high or upper middle income countries, with many coming from prestigious institut

Top journal recognizes Ottawa expertise in patient decision aids


Dr. Dawn Stacey and her colleagues were invited by the prestigious Journal of the American Medical Association (JAMA) to submit a summary of their recent Cochrane systematic review on patient decision aids. The review reports on the effectiveness

The Ottawa Hospital and uOttawa to play lead role in global research ethics collaboration


The Ottawa Hospital and the University of Ottawa are pleased to be among four institutions from around the world selected as pilot members of the Committee on Publication Ethics (COPE). COPE promotes ethical standards for publishing research and provides guidance to more than 10,000 scientific journals and editors. Through a pilot project, COPE is now opening up its membership to selected universities and research institutions for the first time. “Participating in this network will allow us to share some of the best practices we’ve developed and learn from the experiences of others,” said Dr. Duncan Stewart, Executive Vice-President of Research at The Ottawa Hospital and professor at the University of Ottawa. “Research ethics is a priority for The Ottawa Hospital because high quality research drives world-class care for our patients and improves health around the world.” “This international collaboration will play a key role in maintaining the integrity of the University of

Bringing a 'trust but verify' model to journal peer review


Academic journals are increasingly asking authors to use transparent reporting practices to "trust, but verify" that outcomes are not being reported in a biased way and enable other researchers to reproduce the results. To implement these reporting p

The Ottawa Hospital Emergency Surgery Study: A World Leader in the Delivery of High Quality and Efficient Surgical Care


Researchers at The Ottawa Hospital and the University of Ottawa are tackling the often-overlooked issue of delayed emergency surgeries. Emergency surgeries are those needed quickly to treat serious injuries or life-threatening conditions, such as a

Robert Hanlon to retire after helping The Ottawa Hospital become a leader in research


When Robert Hanlon first started working at the former Civic Hospital in 1985, there was a lot of excitement around research but not a lot of action. Today, thanks in part to Hanlon’s contributions, The Ottawa Hospital is one of the top research an

Could stem cells heal premature lungs, fight infections, build muscles and strengthen bones?


Ottawa researchers closer to finding out, thanks to $1.5 million from the Ontario Institute for Regenerative Medicine Researchers from The Ottawa Hospital, CHEO and the University of Ottawa are bringing discoveries made in the lab closer to huma

The Ottawa Hospital awarded 18 research grants from the Canadian Institutes of Health Research, worth $10.7 million


Eighteen research groups at The Ottawa Hospital, affiliated with the University of Ottawa, have been awarded nearly $11 million in the most recent project grant competition from the Canadian Institutes of Health Research (CIHR). This represents a suc

The Ottawa Hospital announces appointment of new Chief Operating Officer for research


The Ottawa Hospital is delighted to announce that Debra Lynkowski has accepted the position of Chief Operating Officer (COO) for the hospital’s research institute. She will assume her responsibilities at the end of June, 2017, after the retirement of

Cord blood therapies: researchers to separate hope from hype thanks to $100,000 grant


Stem cell therapies based on umbilical cord blood hold significant promise, but few have been scientifically proven. Dr. David Allan was awarded $100,000 from Canadian Blood Services (CBS) to develop policies around the use of cord blood that will protect Canadians from the possible dangers of unproven therapies. His team will create a continuously updating bank of clinical studies that support the use of umbilical cord blood cell therapies, so Canadians can know which treatments are proven and which are still experimental. They will also identify the gaps between what the clinical evidence shows and what the public expects from these therapies. Finally, the team will develop processes that will ensure fair access to banked cord blood for regenerative therapies, and design search algorithms that are compatible with national and international registries. See CBS blog post for more. Co-investigators: Brian Hutton, Tim Caulfield, Kim Young The Ottawa Hospital: Inspired by research

Tattoo artist grateful to be off blood thinners thanks to made-in-Ottawa rule


Ottawa resident Sarah Rogers would have been taking blood thinners for life, if not for a rule that showed she was at low risk of having a second blood clot. Ottawa tattoo artist Sarah Rogers thought she’d pulled a muscle when her right leg star

Over 10,000 Canadian women per year can stop taking blood thinners for unexplained vein clots


Rule identifies women who have low risk of vein blood clot recurrence A Canadian-led research group has developed and validated a rule that could let half of women with unexplained vein blood clots stop taking blood thinners for life. These find

Retired nurse breathes easily after study finds she was misdiagnosed with asthma


Becky Hollingsworth was one of 613 Canadians who took part in a study that found one third of adults recently diagnosed with asthma do not have it. Thanks to a random phone call, Becky Hollingsworth got to be part of a study that found she did n

How can you avoid a “predatory” journal? New research provides guidance


It is not uncommon for a researcher to receive dozens of emails from “predatory” journals each week. These emails offer to publish academic research in an open access journal, often with rapid peer-review at a discount. But in many cases, they publis

Could a simple blood test improve care for preterm infants in low income countries?


Preterm birth is one of the leading causes of death and illness in newborns around the world. Specialized care can improve the health of preterm infants, but in countries without access to prenatal ultrasounds, it can be difficult to know if a chil

Ottawa researchers to play lead role in new cancer immunotherapy studies


BioCanRx funds research into CAR-T and virus-infected cell therapy Researchers from The Ottawa Hospital and the University of Ottawa will play a lead role in cutting-edge research on cancer immunotherapy, thanks to five new peer-reviewed researc

Researchers tap into human behaviour to improve patient safety


The Canadian Patient Safety Institute (CPSI) announced a new partnership with Dr. Jeremy Grimshaw and his colleagues at The Ottawa Hospital’s Centre for Implementation Research. They will apply their knowledge of implementation and behavioural science to help increase the success of CPSI’s patient safety programs. The partnership is part of the CPSI’s SHIFT to Safety campaign, which aims to give patients, health care providers and organizations the tools and resources they need to keep patients safe in a health care setting. However, for these programs to work they need patients, health-care providers, managers and policy makers to change their behaviours and the choices they make. Dr. Grimshaw and his team will use implementation and behavioural science to identify strategies to support these individuals to make changes that will improve patient safety, such as increased hand-washing. This involves identifying what behaviour needs to be changed, and finding barriers to that change,

Preclinical studies often fail to report key details of experiments


Males and females often respond to drugs differently, so it would seem obvious that when researchers are testing drugs in animal models, they would mention their sex. But new research led by Dr. Marc Avey shows that this isn’t necessarily the ca

Study finds 33% of adults recently diagnosed with asthma do not have it


A new study published in the Journal of the American Medical Association found that 33 percent of adults recently diagnosed with asthma by their physicians did not have active asthma. Over 90 percent of these patients were able to stop their asthma medications and remain safely off medication for one year. “It’s impossible to say how many of these patients were originally misdiagnosed with asthma, and how many have asthma that is no longer active,” said lead author of the study Dr. Shawn Aaron, senior scientist and respirologist at The Ottawa Hospital and professor at the University of Ottawa. “What we do know is that they were all able to stop taking medication that they didn’t need – medication that is expensive and can have side effects.” Eighty percent of the participants who did not have asthma had been taking asthma medication, and 35 percent took it daily. The study also found that doctors often did not order the tests needed to confirm an asthma diagnosis. Instead t

Access to kidney transplants unequal across Ontario: study


A study published in the American Journal of Transplantation found that chronic dialysis patients in Ontario have unequal access to kidney transplants. These patients with kidney failure will be on dialysis their whole lives unless they receive a

Innovative computer tablet could help stroke patients recover


Stroke patients often spend days or weeks recovering in hospital, and while some rehabilitation services are available during this crucial time, many spend hours each day alone and inactive. But now, some stroke patients at The Ottawa Hospital ar

Ottawa researchers develop rapid review process to help WHO respond to global threats


Ms. Chantelle Garritty and collaborators in the Knowledge Synthesis Group have developed a process to help the World Health Organization (WHO) quickly create guidelines during global emergencies. During an outbreak of a new disease, WHO needs to a

Researchers use rigorous approach to establish the strength of lab data to inform stem cell clinical trial


While many exciting discoveries are made in laboratories every year, few ever become successful human treatments. This may be because often the decision to start a human trial is based on a few laboratory studies instead of considering all the av

Three Ottawa-led stem cell trials get $2.2 million boost


Ottawa researchers bring in half of clinical trial awards from Stem Cell Network Could stem cells help the body recover from septic shock, heart attack and liver transplantation? Researchers from The Ottawa Hospital and the University of Ottawa

Algonquin College and The Ottawa Hospital form new partnership


OTTAWA — Algonquin College and The Ottawa Hospital are embarking on a unique partnership in health research, innovation and training. The College has signed a Memorandum of Understanding with the Hospital’s research institute to “encourage and facili

Researchers to identify most promising stroke therapies for clinical trials


Stroke is the third leading cause of death in Canada, and is usually caused by a blood clot in the brain. Currently the only approved drug therapy is a protein called plasminogen activator (tPA), which dissolves the clot. However, researchers hav

Outstanding research on display at the Ottawa Hospital Research Institute’s 16th annual Research Day


The Ottawa Hospital Research Institute’s 16th annual Research Day was a great success, with more than 350 attendees packing the St. Elias Centre to capacity. Designed to highlight and celebrate the outstanding work of trainees, as well as promote scientific interaction, the event featured 127 posters (nearly 114 competing for prizes) and 15 oral presentations. Drs. Duncan Stewart, Bernard Jasmin, Alain Stintzi and Fraser Scott set the stage with introductory remarks, while Dr. Carl June gave the keynote lecture "Engineering T-cells for cancer immunotherapy." Prizes were awarded to the following trainees: Oral Presentation Competition: 1st: Amelia Aitken. An oncolytic virus targeting the RNA interference pathway Co-authors: Bastin D, Pelin A, Pikor L, Huh M, Roy D, Bourgeous-Daigneault MC, Petryk J, Ilkow C, Bell J. 2nd: Vignan Yogendrakumar. Location of Intracerebral Hemorrhage Predicts Hematoma Expansion and Clinical Outcome Co-authors: Andrew M Demchuk

The Ottawa Hospital ranks among Canada’s top research hospitals


The Ottawa Hospital’s research activity totalled $133.7 million in 2014-15, according to data released today by Research Infosource. This places The Ottawa Hospital in sixth spot among Canada’s hospitals and provincial health authorities for research

“Invaluable” study confirms blood thinners don’t prevent recurrent pregnancy complications


Two years ago, Dr. Marc Rodger thought he had settled the debate about the use of blood thinners in pregnant women at high risk of developing blood clots. His trial of 292 women in five countries – the largest of its kind – definitely showed that t

Ottawa researchers take the lead in reducing unnecessary procedures in emergency department


Unnecessary medical procedures waste billions of dollars each year in Canada and cause substantial discomfort and harm to patients. Two high-profile organizations recently recognized the leadership of Ottawa researchers in tackling this problem i

Grandmother saved by diagnosis of rare condition


Anita Brisson learned that she had a condition called Factor XIII deficiency in 2013. She decided to participate in research that could help other patients with this very rare blood disease. Anita Brisson was doing her usual chores in her home

Research in flight: Photos show astronaut participant in Ottawa MARROW study


Photo: NASA NASA Astronaut Jeff Williams conducts a breath sample collection for the Canadian experiment MARROW on board the International Space Station. MARROW studies how a lack of physical activity affects the bone marrow production of norm

Sepsis deaths plummet after implementation of new emergency department protocol


Sepsis is a life-threatening condition that occurs when an infection spreads throughout the bloodstream. It affects approximately 30,000 Canadians each year and carries a death rate much higher than other critical conditions treated in the emerge

Can pneumonia cause inflammation in the blood vessels? Researchers get $153,000 grant to find out.


Drs. Vicente Corrales-Medina and Girish Dwivedi were awarded $153,000 from the Heart and Stroke Foundation to investigate whether pneumonia can cause inflammation in the arteries of older patients. Their team previously found that after patients over 65 had developed pneumonia, their risk of cardiovascular disease rose two- to four-fold. The biological reason for this is currently unknown. Studies in animal models suggest that pneumonia can increase inflammation of the arteries, which has been linked to a higher risk of heart disease. The research team will further investigate this possibility by comparing the artery inflammation levels in pneumonia patients over age 65 with those of patients who have not had pneumonia. This is one of five Heart and Stroke Foundation grants recently awarded to researchers at The Ottawa Hospital / uOttawa. Co-investigators: Monica Taljaard, Robert DeKemp, Lionel Zuckier, Robert Beanlands h3>The Ottawa Hospital: Inspired by research. Driven by c

Want to know how long you’ll live? There’s a calculator for that


A creative tool by senior scientist Dr. Doug Manuel and his team helps show why public health research matters. Calculators are great for dividing up restaurant bills, but what about one that estimates how long you’re going to live? Dr. Doug M

Decision-making strategy aims to empower First Nations, Inuit and Métis patients


Postdoctoral fellow Dr. Janet Jull is tailoring and testing a peer-support shared decision-making strategy and guide to better meet the health-care needs of First Nations, Inuit and Métis. While working as an occupational therapist with Inuit

Ottawa team pioneers new approach for cancer clinical trials


What is the most efficient way to answer the most important questions to improve care for cancer patients? Drs. John Hilton, Mark Clemons and Dean Fergusson got a group of Ottawa researchers together to answer this question and came up eight key principles, which form the basis for their Rethinking Clinical Trials (REaCT) Program. As described in the Journal of Oncology Practice, REaCT involves comparing different approved treatment strategies rather than developing new ones. It also involves a streamlined process for obtaining oral (rather than written) patient consent, immediate randomization into treatment groups using a mobile device and simplified data collection. Their first trial, which compares two strategies to prevent chemotherapy-related infections in breast cancer patients, has recruited nearly 150 patients in just over 18 months, at a small fraction of the cost of most cancer clinical trials. Nine other REaCT cancer trials are currently underway (with support from the

Ottawa-led team gets top rank for patient decision aids research


Dr. Dawn Stacey has earned the distinction of having her Cochrane systematic review cited more than any other review in 2015. According to The Cochrane Library, of more than 1,800 reviews published in 2013-2014, “Decision aids for people facing h

Could a "metabolic fingerprint" identify premature babies in developing countries?


Canadian-led team awarded US $1.2 million from the Bill & Melinda Gates Foundation to investigate What if a blood spot from a newborn could identify vulnerable children at birth? One of the biggest vulnerabilities is being born premature. Cana

The Ottawa Hospital awarded $27 million from Canadian Institutes of Health Research for 13 research projects


Thirteen teams at The Ottawa Hospital, affiliated with the University of Ottawa, have been awarded more than $27 million in the latest round of research grants from the Canadian Institutes of Health Research (CIHR). Four of The Ottawa Hospital’

Maternal and child health research gets $9.8-million boost


The Ottawa Hospital ranks well above national average in most recent competition from Canadian Institutes of Health Research If folic acid prevents birth defects during the first trimester, should it be taken throughout pregnancy? Dr. Mark Walker and Dr. Shi Wu Wen at The Ottawa Hospital and the University of Ottawa can now definitively answer this question after being awarded a $9.8 million Foundation Grant from the Canadian Institutes of Health Research (CIHR). The grant is one of 13 recently awarded to The Ottawa Hospital in CIHR’s latest competition, worth a total of $27 million. “People think folic acid is a harmless supplement, so many mothers take it even after the recommended first trimester and in higher doses than recommended” said Dr. Walker, a senior scientist and Department Chief of Obstetrics, Gynecology and Newborn Care at The Ottawa Hospital and Department Chair of Obstetrics and Gynecology at the University of Ottawa. “The results of this study will tell us on

$150,000 grant to help researchers test whether exercise before surgery can help elderly patients recover


Dr. Daniel McIsaac and his team were awarded $US 150,000 by the International Anesthesia Research Society to test whether home-based exercise training before cancer surgery can improve the outcomes of frail elderly patients. This population is at

Unhealthy habits cost Canadians 6 years of life


Study looks at impact of smoking, poor diet, physical inactivity and alcohol Unhealthy habits are costing Canadians an estimated six years of life, according to a study published today in PLOS Medicine. Researchers found that smoking, poor di

The Ottawa Hospital General Campus to be a test ground to compare two rehydration fluids


Starting August 2016, a pilot study at the General Campus of The Ottawa Hospital will help find out which of two liquids is the best to replace lost fluids in hospitalized patients. A healthy person’s bodyweight is about 60 percent water. How

$4.2M grant to advance development of next-generation regenerative therapies for vascular disease


Dr. Duncan Stewart has been awarded $4.2M from the Canadian Institutes of Health Research (CIHR) to advance our understanding of vascular disease and develop next-generation regenerative therapies. Dr. Stewart and his team have already initiated

Researchers find unexpected association between younger donor age, female sex and transfusion outcomes


A large Canadian study has shown a link between blood donor characteristics and transfusion recipients’ outcomes. This is the first study to suggest that red blood cell transfusions from young donors and from female donors may be associated with

Decision aid helps people with rectal cancer make tough choices


The good news about rectal cancer is that it is often curable through surgery. The bad news is that depending on which kind of surgery is performed, patients can either end up with a significant risk of incontinence or a permanent colostomy (in w

When is fainting a sign of a bigger problem?


Researchers develop new screening tool to help emergency physicians A simple nine-question tool could help emergency physicians uncover the dangerous hidden conditions that make some people faint, according to a study published today in the Ca

Bringing the beat back: $900k grant to help researchers compare fixes for rapid heartbeat


It’s common for doctors in medical dramas to use a defibrillator to shock a patient back to life. However, the same machine can also help a heart that’s beating too fast. About 350,000 Canadians have atrial fibrillation (AF), a rapid, irregular h

To treat, or not to treat? How one man decided to keep his prostate cancer


Stephen Wilson of Iroquois, Ontario avoided unnecessary treatments and side-effects by opting for regular monitoring of his slow-growing prostate cancer. Dairy plant manager Stephen Wilson faced a tough choice. In December 2012, he had just be

Ottawa research informs international Ebola guideline


Should clinicians wear double gloves or single gloves when caring for Ebola patients? What about full gowns versus coveralls? After Ebola broke out in West Africa in late 2013, the World Health Organization (WHO) asked Dr. David Moher and his tea

15 tips for giving feedback to health-care providers


A key tool for improving quality in health care is to audit how it is being provided and give feedback on how to improve. However, some kinds of feedback are more helpful than others. Dr. Jamie Brehaut and colleagues set out to learn what feedbac

The wrinkle review: study finds more evidence needed to compare anti-wrinkle drugs


Ottawa researchers are known around the world for conducting systematic reviews to rigorously compare different medical treatments, but occasionally they also use this expertise to answer important non-medical questions. For example, Dr. James Bo

Canadian-led guideline improves health research around the world, but more work required


A decade after cataloguing the abysmal state of systematic reviews of health research and creating the PRISMA guideline to improve things, Dr. David Moher and his colleagues have found that things have improved but more work is required. “Syst

Can a drug help prevent blood loss during bladder cancer surgery?


Drs. Rodney Breau, Ilias Cagiannos, and Franco Momoli were awarded $400,000 from the Canadian Institutes of Health Research (CIHR) to investigate whether a drug called tranexamic acid can reduce blood loss during surgery for patients with bladder

Out-of-this-world research could help rehabilitation patients in Ottawa


Entrepreneur Raymond Nicholas spent three months in a hospital bed and another three learning how to walk again. His doctor Dr. Guy Trudel is studying astronauts’ health in space, which he hopes will lead to faster rehabilitation for patients like Ni

Dr. Ian Graham awarded $3.3M to tackle the challenge of effectively applying health research to health care


The ultimate goal of most health research is for the results to be put into practice. Unfortunately, this doesn’t always happen. In many cases, research findings are applied very slowly to everyday health care or not at all. Failing to put research i

Ottawa researchers shine in SPOR funding announcement


Researchers from The Ottawa Hospital are playing a lead role in two of the five chronic disease networks recently funded by Canada's Strategy for Patient-Oriented Research (SPOR), managed by the Canadian Institutes for Health Research. Dr. Patric

Man survives severe infection after participating in world-first stem cell trial at The Ottawa Hospital


Stem cells are usually thought of as the building blocks of the body – able to give rise to all our cells and organs. But a clinical trial at The Ottawa Hospital is testing the idea that certain stem cells may also be able to help control the body’s

Breakthrough tuberculosis drug now available through Canadian study: Taima TB 3HP study launched in Iqaluit and Ottawa


Tuberculosis (TB) is a major public health threat in Canada’s North, with an incidence rate up to 40 times greater than the national average. Now residents of Iqaluit and Ottawa can enroll in a study of a new drug combination that reduces the treatme

Hot off the press! New edition of EPIgram just published


Are your submitted manuscripts the best they can be? Learn how publications officer Kelly Cobey can help get your manuscripts published faster and with fewer revisions by reading the latest edition of EPIgram. Published by the Ottawa Hospital Res

Research in flight: Video shows astronaut participant in Ottawa MARROW study


A new video from the Canadian Space Agency (CSA) features European Space Agency Astronaut Tim Peake explaining the MARROW study aboard the International Space Station. The video gives a unique glance into research led by Dr. Guy Trudel, a professor at the University of Ottawa and Physiatrist at the Rehabilitation Centre of The Ottawa Hospital. His team is studying the bone marrow health of 10 astronauts over the course of their six-month missions as well as the year after they return. While ground staff conduct the pre- and post- flight blood and assist with breath sampling, the astronauts take these samples all by themselves once they’re in space. The weightless environment adds extra challenge to procedures like taking blood or breath and Dr. Trudel’s team worked with the CSA team to come up with a working solution for the breath samples. The goal of the study is to gain better understanding of the effects of extended space travel on bone marrow health and blood cell metabolism, find

$2.1M grant to help find better ways to bring research results to life


Dr. Jeremy Grimshaw and his team were awarded a $2.1M Foundation grant from the Canadian Institutes of Health Research to develop better strategies for applying research findings to health care, a process called knowledge translation or KT. His t

Fighting back against chronic nerve pain: researchers get $295K to test combination therapy


During their war with cancer, it’s common for survivors to find themselves in a new battle with chronic nerve pain. Either damaged by the disease or the treatments used, some of their nerves start sending incorrect signals causing shooting, burni

Small cuts, big outcomes: study shows less invasive hysterectomies helped patients heal and saved The Ottawa Hospital money


A move by The Ottawa Hospital to promote less invasive surgeries for women with severe gynecological problems has sped up patient recovery, led to fewer complications and saved the hospital money, according to a study recently published in theJourn

Many prostate cancer patients saved from unnecessary treatments and side effects


Low-risk patients increasingly undergoing regular monitoring rather than immediate treatment Of the approximately 24,000 Canadians diagnosed with prostate cancer each year, about half have a slow-growing form that poses little risk to their he

2015’s most cited PAIN paper written by Ottawa researchers


Could an antiepileptic drug reduce pain after all kinds of surgery? Dr. Naveen Eipe and colleagues were awarded Most Cited Paper of 2015 by the journal PAIN for their attempt to answer this controversial question. Pregabalin was originally approv

Drs. Grimshaw and Moher among “world’s most influential scientific minds”


Drs. Jeremy Grimshaw and David Moher recently made a list of the world’s top 3,000 researchers. This puts them in the top 0.03 percent, as it is estimated that there are more than 9 million researchers worldwide. The list of the “world’s most influ

Can smartphone-assisted therapy help prevent suicide? Researchers get $1.7M grant to find out


Every year about 1,200 people in Ottawa arrive at a hospital with self-harm, usually from an overdose of pills. About five percent of these people will die by suicide in the next five years. However, the treatment given to this high-risk group is

Controversial prostate cancer screening can be improved by repeating abnormal tests


For more than 20 years, the prostate-specific antigen (PSA) test has been used to help screen for prostate cancer, but in recent years, some task forces have called for this blood test to be abandoned because it leads to many unnecessary biopsies. No

Ottawa researchers call for better tools to combine health data


Health data has never been more plentiful, from the millions of research studies published every year, to data from personal genome sequencing, electronic health records and wearable devices. Yet sifting through this information to make evidence-base

Landmark folic acid trial in pregnant women recruits final patient


After 54 months, one of The Ottawa Hospital’s largest randomized controlled clinical trials has recruited its final patient – number 2,464. The trial, led by Drs. Mark Walker and Shi Wu Wen, is evaluating the effectiveness of the vitamin folic acid in preventing preeclampsia in pregnant women in five countries. Preeclampsia affects about five per cent of pregnant women worldwide, and is characterized by high blood pressure and leakage of protein into the urine. Preeclampsia is responsible for one-third of all pregnancy-related deaths worldwide. Currently, the only way to cure preeclampsia is to deliver a baby – which often happens well before the due date resulting in preterm births. The results could change medical practice worldwide. See International Innovation for details. About The Ottawa Hospital The Ottawa Hospital is one of Canada’s largest learning and research hospitals with over 1,100 beds, approximately 12,000 staff and an annual budget of over $1.2 billion. Our focus

Applauding our Leading Researchers and Their Accomplishments at The Ottawa Hospital Gala


Ottawa’s glitterati, including community and businesses leaders, joined local researchers in honouring their peers at The Ottawa Hospital Gala presented by Nordion. In particular, three researchers were feted for their groundbreaking work and innovat

Study investigates progress in increasing value in biomedical research


Biomedical research is essential for improving health, but evidence suggests that we are not deriving maximum benefit from the research that’s being done. This can be because of poor research questions, poor study design and poor (or no) reporting of

Ottawa Subarachnoid Hemorrhage Rule could save $25 Million in Ontario


With headache as its predominant symptom, subarachnoid hemorrhage (SAH) can be challenging to diagnose. It is estimated that close to 50 patients presenting with SAH in Ontario annually are misdiagnosed at the time of their first hospital visit and h

Clinical epidemiology newsletter highlights IQ@TOH, a new initiative to harness research to improve quality of care


The sixth edition of the Clinical Epidemiology Program’s EPIgram newsletter is now available, including a cover story on IQ@TOH, a new initiative to harness research to improve quality of care at The Ottawa Hospital. The newsletter also features Dr.

Dr. Greg Knoll awarded $3.9 million to create and translate knowledge in kidney transplantation


Dr. Greg Knoll is one of a seven scientists at The Ottawa Hospital recently awarded Foundation Grants by the Canadian Institutes of Health Research. Dr. Knoll’s team will receive $3.9 million over seven years to undertake patient-centred research rel

Research study informs new program to prevent sexual assault at large gatherings


For Dr. Kari Sampsel, treating sexual assault victims in The Ottawa Hospital’s emergency department was not enough. She also wanted to help prevent sexual assault, and to do that, she needed to understand the risk factors. So Dr. Sampsel and her coll

Dr. Bernard Thébaud’s team receives $3.2 million to develop stem cell therapy for babies with lung disease


Dr. Bernard Thébaud’s team is one of seven at The Ottawa Hospital recently awarded Foundation Grants by the Canadian Institutes of Health Research. Thébaud’s team has received $3.2 million over seven years to develop three different kinds of stem cell treatments for babies with life-threatening lung diseases. The three approaches focus on mesenchymal stem cells, endothelial progenitor cells and induced pluripotent stem cells. “We are one of the very few labs in the world,” Thébaud told the Ottawa South News in a recent interview, “that is banking on the therapeutic potential of these stem cells that may likely revolutionize medicine and we are the only lab working on three types of stem cell products.” Currently the therapies keeping these babies alive can seriously damage their lungs, leading to emphysema and high blood pressure in the lungs later in life. Stem cells have the ability to repair damaged lung tissue, promote lung growth or correct genetic mutations. Cocherc

Are predatory journals filling up your inbox? New research explores the problem


Are those electronic invitations filling your inbox from so-called credible medical journals worth a second glance? Authors often feel pressure to publish, but competition can be stiff and determining where to submit time-consuming. Dr. David Moher

New research reporting guideline helps compare multiple treatments


How do the dozens of available hypertension drugs stack up against each other? What about anti-depressants? And anti-bleeding drugs? These are just a few of the important questions that Dr. Brian Hutton and his colleagues are answering through netw

The Ottawa Hospital awarded $28M from Canadian Institutes of Health Research for 22 research projects


Twenty-two teams at The Ottawa Hospital, affiliated with the University of Ottawa, have been awarded more than $28 million in research grants from the Canadian Institutes of Health Research (CIHR). The Honourable Rona Ambrose, Minister of Health for

Jean Maroun Scholarship recognizes resident’s research to help manage chemotherapy side effects


Post-graduate medical oncologist Dr. Terry Ng is the first recipient of the Jean Maroun Resident Research Scholarship, which will be presented annually to a resident whose research results have the potential to change practice. Dr. Ng’s research f

Are generic immunosuppressants safe and effective?


That is the question that Dr. Greg Knoll set out to research when he was asked to debate the topic during the 2014 annual meeting of the Canadian Society of Transplantation. Together with research fellow Dr. Amber Molnar, Dr. Dean Fergusson and other

Save Cochrane Canada, a pioneer in evidence-based medicine, based at The Ottawa Hospital


Cochrane Canada, based at The Ottawa Hospital and led by Dr. Jeremy Grimshaw, is set to close when it’s funding runs out in September 2015. Its primary funder, the Canadian Institutes of Health Research (CIHR) has not renewed its support. Cochrane Canada is part of an independent global network of over 30,000 healthcare practitioners, researchers, patient advocates and others. Cochrane works to turn the evidence generated through research into useful information for making everyday decisions about health. Cochrane Canada was established in 1993 and is one of 14 centres worldwide. More than 120 countries belong to this non-profit collaboration. This funding decision is not based on the organization’s performance, but rather on changes to the CIHR grant structure. Cochrane Canada is undertaking a campaign to try to help keep its doors open and is asking for your help. Find out how you can help to #saveCochraneCanada. For further information, please contact Lois Ross Senior Communic

New research chair will focus on turning research results into action


Dr.Janet Squires has been appointed University Research Chair in Health Evidence Implementationfor the uOttawa Faculty of Health Sciences’ School of Nursing. Dr. Squires will focus her extensive experience on implementation science and knowledge translation, showing how research results can be leveraged to improve health-care practice and outcomes for patients. For example, Dr. Squires is studying strategies to reduce the overuse of diagnostic imaging in early stage breast cancer. This study will help implement research results recently published by Dr. Mark Clemons and co-authors related to unnecessary imaging in Stage 1 and 2 breast cancer patients. Dr. Angel Arnaout is co-principal investigator on this project. For further information, please contact Lois Ross Senior Communications Specialist Ottawa Hospital Research Institute Office: 613-737-8899 x73687 Cell: 613-297-8315

$1.5M grant could improve care for trauma patients and save $10M per year


Drs. Christian Vaillancourt and Ian Stiell have been awarded $1.5M from the Ontario SPOR (Strategy for Patient-Oriented Research) Support Unit to evaluate a strategy to reduce unnecessary immobilization of trauma patients by paramedics. Currently, pa

Study reveals widespread over-imaging in early stage breast cancer patients in Ontario


Reducing unnecessary imaging could improve care and reduce costs Researchers at The Ottawa Hospital and the University of Ottawa have found that most Ontario women with early stage breast cancer are undergoing unnecessary imaging to determine

Study could reduce unnecessary cancer screening


Large clinical trial shows CT scanning does not improve cancer detection in people with unexplained blood clots A large clinical trial led by researchers at The Ottawa Hospital and the University of Ottawa has found that contrary to expectations, a CT scan of the abdomen and pelvis does not improve cancer detection in people with unexplained blood clots in their legs and lungs. The results, published in the June 22nd edition of the New England Journal of Medicine, are expected to improve patient care and reduce screening costs around the world. More than 500,000 Canadians and Americans are diagnosed with blood clots in the lungs and legs each year (called venous thromboembolism). In some cases, the clots are caused by trauma, surgery prolonged immobility or a known cancer, but in about half of cases, the cause of the blood clots is unknown. “Unexplained blood clots have long been thought of as a possible early warning sign of cancer, with previous studies suggesting that

Tool can accurately predict risk of death within one year of hospital admission


Has someone you love recently been admitted to the hospital? Would you like to know what their chance of dying is within the next year? If so, this can now be easily calculated using the HOMR (Hospital-patient One-year Mortality Risk) model develop

Promising intermediate results in CIHR’s Foundation grant competition


Eight scientists from the Ottawa Hospital Research Institute have moved on to the third and final phase of the Foundation grant competition from the Canadian Institutes of Health Research (CIHR), representing a success rate of 26% (over the first two

Survey of health care providers and patients highlights need for standardization of use of the Breast Cancer drug, docetaxel.


Drs. Mark Clemons and Brian Hutton have published the results of a survey on the use of steroids to prevent adverse reactions in patients receiving docetaxel chemotherapy, one of the most commonly used drugs in breast cancer. The article, publishe

Manosilah Yoganathan recognized for outstanding research in Co-op Program


uOttawa’s Faculty of Graduate and Post-doctoral Studies has named Manosilah Yoganathan the Best Co-op Student of 2014. Working under the mentorship of Dr. Dawn Stacey, Ms. Yoganathan developed one-page patient decision aids based on research evidence

Tender Loving Research helping people requiring blood transfusions


The latest edition of our Tender Loving Research video blog features Dr. Dean Fergusson explaining the motivation behind his research on blood transfusions. More than a million blood units are transfused in Canada every year, saving countless lives,

Old blood as good as fresh in patients with life threatening illnesses


Just like milk and many other foods, blood used for transfusions is perishable. But contrary to popular belief, new research shows that blood stored for three weeks is just as good as fresh blood — findings published today in the New England Journal

Most clinical trials of 'stalled drugs' do not report results


Lots of potentially useful medical information is getting lost. Researchers from McGill University, The Ottawa Hospital and the University of Ottawa discovered this when they looked for results of clinical trials of “stalled drugs” – drugs that showe

Dr. Jeremy Grimshaw honoured as a Fellow by Scotland's national academy


Dr. Jeremy GrimshawJeremy Grimshaw has been named a Fellow of the Royal Society of Edinburgh (RSE), along with an elite group of "outstanding scientists, celebrated writers and eminent academics." He became a Corresponding Fellow, which is an honour

Research could lead to better diagnosis of recurrent blood clots


Dr. Grégoire Le Gal has been awarded a $235,000 grant from the Heart and Stroke Foundation for research that could enhance the diagnosis of blood clots in the veins of the legs and lungs. This condition, called venous thromboembolism or VTE, affe

Ottawa COPD Risk Scale could save Ontario $115M over 3 years


An economic analysis recently published by the Council of Academic Hospitals of Ontario (CAHO) finds that the Ottawa COPD Risk Scale, developed by Dr. Ian Stiell and colleagues, could save Ontario’s health-care system as much as $115M over three year

Neither oral nor intravenous Vitamin C improve cancer treatment


Dr. Mark Clemons recently published a comprehensive review of existing studies to determine whether there is scientifically compelling evidence to support the use of Vitamin C in cancer treatment, either to enhance chemotherapy or reduce its toxicity

Flu shots decrease overall risk of acquiring Guillain-Barré Syndrome


Drs. Kumanan Wilson and Steven Hawken published a paper this week that examines whether the flu shot increases or decreases the risk of getting Guillain-Barré Syndrome (GBS), a rare but serious autoimmune condition. Recent studies have associated

Does a blood donor’s age or sex affect outcomes for transfusion recipients?


Every year in Canada, more than 1.5 million blood products (red blood cells, platelets, plasma and others) are transfused into patients, often in lifesaving situations. However, it is unclear whether certain donor characteristics — such as age, sex a

Blood thinner study in pregnant women receives national award


Dr. Marc Rodger recently received the Canadian Hematology Society’s clinical paper of the year award for his international clinical trial of blood thinners in pregnant women, published in The Lancet. The trial showed that daily blood thinner injectio

Evidence and guidelines say don't image, yet oncologists still do


Despite multiple evidence-based guidelines recommending against imaging for metastatic disease in patients with early-stage breast cancer, many physicians continue to order such tests. A paper published by Drs. Demetrios Simos, Mark Clemons and Brian

Surprising study could save lives of kidney transplant patients


Keeping kidney transplant patients healthy requires a fine balance, because the drugs that prevent transplant rejection can also increase the risk of cancer. Sirolimus was once thought to be a promising new kidney transplant drug, because it seemed t

Reducing unnecessary and harmful care for kidney transplant patients


Kidney transplantation is life-changing and even life-saving for hundreds of Canadians every year, but in about 30% of patients, the drugs that prevent organ rejection also allow the normally harmless BK virus to replicate out of control, potentially

Simple stroke care improvements can dramatically reduce disability and death


Dr. Jeremy Grimshaw is part of an international team that recently received a prestigious award for developing an evidence-based training program that reduced disability and death from stroke by a “remarkable” 16% and reduced hospital stays by two

Understanding the risks that lead to complications after bladder cancer surgery


Drs. Rodney Breau and Luke Lavallée have published a new study in PLOS ONE regarding complications following the removal of the bladder to treat bladder cancer (radical cystectomy). The study found that 55% of patients experienced a post-operative complication following such a surgery, the most common of which was the need for a blood transfusion (38% of patients). It also identified risk factors for experiencing a post-operative complication, which included older age, female gender, pre-operative health status, chronic obstructive pulmonary disease, low serum albumin, radiotherapy, recent transfusion, and length of operation. Radical cystectomy is often the best treatment option for patients with bladder cancer, but the high risk for complications associated with this procedure warrants more studies to improve patient safety. Dr. Breau and his colleagues have previously identified that lysine inhibitors (to prevent bleeding during surgery) are underutilized for patients receiving ra

Developing a tool to assess the risk of cardiovascular disease among certain populations


Drs. Doug Manuel and Monica Taljaard have published a protocol in the online medical journal BMJ Open to develop a new tool designed to assess the risk of people developing cardiovascular disease among certain populations. They will develop, evaluate

Study shows discrepancy in quality of oncology literature


Drs. Carmel Jacobs and Mark Clemons led a team to evaluate the quality of oncology guidance documents. Recently published in PLOS One, the study shows a discrepancy in the quality of published Consensus Statements compared to Clinical Practice Guidel

Canadian chapter of EQUATOR launched in Ottawa


The Ottawa Citizen published an article this past week concerning the launch of the Canadian chapter of EQUATOR at The Ottawa Hospital. Founded in Britain in 2006, EQUATOR suggests guidelines for how scientists publish their discoveries. It aims to improve the trustworthiness of biomedical journals, which publish the latest medical research news. Dr. David Moher, who was on hand to launch EQUATOR’s Canadian chapter, told the Ottawa Citizen newspaper that OHRI plans to train a publications officer who will check manuscripts before they’re submitted for publications. Read the article. About the Ottawa Hospital Research Institute The Ottawa Hospital Research Institute (OHRI) is the research arm of The Ottawa Hospital and is an affiliated institute of the University of Ottawa, closely associated with the university’s Faculties of Medicine and Health Sciences. OHRI includes more than 1,700 scientists, clinical investigators, graduate students, postdoctoral fellows and staff conducting r

Simple method proves equally good at predicting kidney transplant outcomes


A team led by Drs. Greg Knoll and Ayub Akbari have published a paper in the American Journal of Kidney Diseases that looks at methods for predicting the outcomes of kidney transplants. The study involved 207 kidney transplant recipients and looked at

$3.85M research grant links naturopathic and conventional medicine in fight against cancer


OTTAWA – Ottawa researchers are receiving the largest-ever North American grant intended to study the effectiveness of naturopathic medicine used in combination with conventional medicine. The funding was announced today by the Ottawa Integrative Can

Assessing the most effective times of day to take urine tests among pregnant women


Dr. Mark Walker has published a paper in the Journal of Exposure Science and Environmental concerning the use of urine tests taken from women during pregnancy to analyze levels of phthalates and bisphenol A (BPA). BPA is thought to disrupt normal hor

Peer reviewers need training, argues Dr. Moher


In the latest edition of Biome, Dr. David Moher makes a case for more rigorous peer -review training among academic and medical institutions, and says that “If journals are to remain relevant for disseminating research in the 21st century we need to

Analysis in CMAJ counters criticisms of pivotal BART trial


In a paper published by CMAJ, Drs. Dean Fergusson, Brian Hutton and colleagues refute three major criticisms of the BART trial, criticisms that were used as justification to bring aprotinin back on the market with revised warnings in Canada and in Eu

Book provides best practices for reporting health research


Dr. David Moher is the lead editor on a new book titled “Guidelines for Reporting Health Research" that has just been published by Wiley Press.The book aims to help researchers choose and use the correct guidelines for reporting their research, and t

Improving how knowledge gets into practice: You have to know the context


Dr. Janet Squires has been awarded a two-year grant worth $264,237 from the Canadian Institutes of Health Research (CIHR) to help our understanding of the role context plays in knowledge translation. Context is increasingly recognized as a central influence on health-care professionals' use of research. This project is necessary to develop common tools for assessing context in order to tailor the design and delivery of knowledge translation interventions, to interpret their effectiveness and to guide knowledge users in their implementation efforts. Grant summaries are available through CIHR’s Funded Research Decision Database. About the Ottawa Hospital Research Institute The Ottawa Hospital Research Institute (OHRI) is the research arm of The Ottawa Hospital and is an affiliated institute of the University of Ottawa, closely associated with the university’s Faculties of Medicine and Health Sciences. OHRI includes more than 1,700 scientists, clinical investigators, graduate students

Decision-aids review: 2013's most cited in The Cochrane Library


Dr. Dawn Stacey has earned the distinction of having one of her Cochrane systematic reviews cited more than any other Cochrane Review in 2013. According to The Cochrane Library, of more than 5,000 reviews, “Decision aids for people facing health trea

Patient’s question triggers important study about blood thinners


Ottawa – Physicians around the world now have guidance that can help them determine the best oral blood thinners to use for their patients suffering from blood clots in their veins, thanks to a patient of The Ottawa Hospital who asked his physician a

Grant awarded for research into complications associated with prostate surgery


Dr. Rodney Breau has received a 2014 Movember Discovery Grant for $200,000 from Prostate Cancer Canada to further his research on the long-term effects of having a prostate surgically removed. Dr Breau and his team will use the funding to study how regular feedback to surgeons, through a surgery report card, could change surgical performance. Surgeons who perform radical prostatectomy will receive feedback every three months on their patient outcomes compared to the outcomes of patients treated by other surgeons. The hope is that regular feedback to surgeons will reduce long-term urinary and sexual side effects that some patients experience after having their prostate removed. See release from Prostate Cancer Canada. About the Ottawa Hospital Research Institute The Ottawa Hospital Research Institute (OHRI) is the research arm of The Ottawa Hospital and is an affiliated institute of the University of Ottawa, closely associated with the university’s Faculties of Medicine and Health S

Clinical trial launched to research the benefits of taking folic acid during pregnancy


Drs. Mark Walker and Shi-Wu Wen have launched a clinical trial to evaluate the effectiveness of folic acid in preventing preeclampsia in pregnant women. Preeclampsia affects about five per cent of pregnant women worldwide, and is characterized by hig

Reducing bleeding and blood transfusions during pelvic surgery


Drs. Rodney Breau, Alan Tinmouth, Dean Fergusson and Franco Momoli have published a study in Transfusion Medicine Reviews that examines the effectiveness of medications to reduce bleeding during pelvic surgery. Surgery in the pelvic area is inherently difficult and may result in heavy bleeding that requires patients to undergo blood transfusions. The authors assessed the safety and efficacy of a class of medications called lysine analogs. Lysine analogs are commonly used during cardiac surgery and are relatively inexpensive. In the current publication, Breau and colleagues evaluated all of the available evidence evaluating lysine analogs during pelvic surgery. They found that this class of medication seems to be safe for patients, while reducing bleeding and blood transfusion requirements. In a previous study, Dr. Breau’s team showed that lysine analogs are not commonly used during pelvic surgery and they are now leading a multicenter prospective trial to verify the effect of lysine a

Deciding whether to stay in your own home or move to a care facility


Dr. Dawn Stacey has been awarded a four -year grant valued at $680,555 from the Canadian Institutes of Health Research (CIHR) to train health providers in home -care teams across Quebec in shared decision making regarding seniors and their decision to continue living in their home or move to a care facility. This decision is one of the toughest for older Canadians to make. Decisions related to living environments that are informed, shared and supported produce better results. An inter-professional approach to shared decision-making is when seniors and their caregivers collaborate in making decisions with two or more professionals involved in their care. Dr. Stacey plans to assess the program's impact by measuring to what extent seniors say they took part in the decision-making process. She and her team will also look at the option each senior chose, whether they regret their decision, its impact on their quality of life, and how much health-care providers involved their patients in the

Common blood thinner for pregnant women proven ineffective: Lancet study


OTTAWA – It's a daily injection to the belly for pregnant women at risk of developing blood clots and it's ineffective, according to a clinical trial led by researchers at The Ottawa Hospital and published today by the prestigious medical journal The

How effective is the peer review process?


Larissa Shamseer, a PhD student working with Dr. David Moher , has published a paper in the British Medical Journal that examines the effectiveness of the peer review process. Although peer reviewing manuscripts has been around for more than 200 years, there is very little hard evidence concerning the effectiveness of the peer review process at improving the reporting in today’s biomedical journals. Ms. Shamseer was part of a team that reviewed 93 articles that had undergone the peer review process. They concluded that peer reviewers failed to detect important deficiencies in the reporting of the methods and results in many randomized trials. Also, the number of changes requested by peer reviewers was relatively small. However, most authors did comply with recommendations they received. Adherence to reporting checklists by journal editors, peer reviewers and authors could improve the reporting of published articles, according to Ms. Shamseer’s paper. Read the full paper. About the O

Fighting tuberculosis in Canada’s North with community-based approach


OTTAWA – While the incidence of tuberculosis remains low in Canada overall, it continues to be a significant public health concern in the North. Researchers at The Ottawa Hospital working with community partners have found a novel way to improve dete

Dr. David Moher named top researcher in new international report on science


Dr. David Moher has made an international list of the world’s top researchers compiled by media company Thomson Reuters. Dr. Moher was the only researcher from OHRI, and one of only four scientists from Ottawa, named to the list, which included 3,200

$8.4M in operating grants from the Canadian Institutes of Health Research (CIHR)


Ottawa Hospital Research Institute scientists were awarded 11 operating grants worth $8.4 million in the most recent CIHR competition. The successful principal investigators and co-principal investigators affiliated with OHRI include Drs. Gonzalo Al

Examining the effectiveness of research reporting guidelines


Dr. David Moher has published a study in The British Medical Journal that calls into question the widespread endorsements given to various research reporting guidelines. Dr. Moher and his team conducted a systematic review of more than 100 guidelines

Shorter, daily dialysis reduces need for blood pressure medication


A clinical trial led by Drs. Deb Zimmerman and Kevin Burns shows that fewer medications are needed to control blood pressure just as effectively when patients undergo daily two-hour hemodialysis sessions. The conventional treatment is three times a w

Getting heart attack patients to follow doctors' orders


Dr. Jeremy Grimshaw has been awarded $1 million from the Ontario Ministry of Health and Long-Term Care to study different ways to get people who have suffered a heart attack to continue rehabilitation and take their medication. Previous studies show that, a year after a major heart attack, just 30% to 40% go to rehabilitation and only 50% take their medications properly. The multi-site study will be based out of Women’s College Hospital in Toronto, and Dr. Noah Ivers will co-lead the study along with Dr. Grimshaw. The research will examine the effectiveness of different ways to get heart attack patients to follow their treatment plans. Strategies will include reminder letters, automated phone calls, follow-up phone calls from nurses, and a combination of all three methods to see which is most effective. The cost of each strategy will also be analyzed. About the Ottawa Hospital Research Institute The Ottawa Hospital Research Institute (OHRI) is the research arm of The Ottawa Hospita

Inspiring shared decision-making: Dawn Stacey influences major academic hospital


One of the Netherland's largest hospitals has signed an agreement to implement shared decision-making and invited Dr. Dawn Stacey to give the 16th Anna Reynvaan Lecture at the Academic Medical Centre of the University of Amsterdam. Last week, Dr. Stacey gave a lecture entitled “Shared Decision-Making: What is the role for nurses?” This annual lecture aims to educate and inspire nurses and other healthcare professionals in the Netherlands and Belgium. About the Ottawa Hospital Research Institute The Ottawa Hospital Research Institute (OHRI) is the research arm of The Ottawa Hospital and is an affiliated institute of the University of Ottawa, closely associated with the university’s Faculties of Medicine and Health Sciences. OHRI includes more than 1,700 scientists, clinical investigators, graduate students, postdoctoral fellows and staff conducting research to improve the understanding, prevention, diagnosis and treatment of human disease. Media contact Paddy Moore Communicati

Government of Ontario invests more than $1 million in multi-year COPD research


Dr. Shawn Aaron is co-lead on a research project into chronic obstructive pulmonary disease (COPD) that has been awarded $1.1 million over three years by the Ontario Ministry of Health and Long-Term Care. Together with Dr. Andrea Gershon, Dr. Aaron w

Canadian Blood Services funds research into transfusion medicine


Alan Tinmouth and the University of Ottawa Centre for Transfusion Research (UOCTR) have been awarded $718,286 by Canadian Blood Services. Dr. Tinmouth heads up the centre, which is a multidisciplinary group of researchers in hematology, nephrology, s

Predicting whether a patient on life support is ready to breathe on their own


Dr.Andrew Seely has published a paper in Critical Care concerning a technique for predicting the successful removal of breathing tubes from people who are on life support. The five-year study involved 721 patients in 12 centres across North America, including Ottawa, Toronto, Vancouver and Cleveland, Ohio. Being able to accurately predict the likelihood that someone on life support will be able to breathe on their own is important as 12% to 15% of these people fail to do so when their breathing tube is removed. Reinserting a breathing tube is extremely stressful on the body and can cause death in severe cases. Dr. Seely hopes to use the findings from the study in his development of technology for use in Intensive Care Units that will measure the respiratory and heart rate variability of patients, and give physicians a better predictor of whether a person is likely to struggle without a breathing tube. Read the paper. About the Ottawa Hospital Research Institute The Ottawa Hospital

Process developed for making healthcare training videos


Dr. Dawn Stacey, a Registered Nurse, has published a paper in the Journal of Interprofessional Care that looks at how to develop a systematic approach to creating training videos to improve shared decision making among health-care professionals. The systematic approach involved everything from deciding on relevant content to drafting a script and evaluating the completed video. The video development process resulted in a product that was true-to-life and improved knowledge among health-care workers. This process could be used to create videos in a variety of health-care contexts. Read more. About the Ottawa Hospital Research Institute The Ottawa Hospital Research Institute (OHRI) is the research arm of The Ottawa Hospital and is an affiliated institute of the University of Ottawa, closely associated with the university’s Faculties of Medicine and Health Sciences. OHRI includes more than 1,700 scientists, clinical investigators, graduate students, postdoctoral fellows and staff cond

Study to explore why people plan to get healthy, but don't


Dr. Janet Squires has been awarded $99,852 by the Canadian Institutes of Health Research (CIHR) to study the plans people make to change their behaviour and improve their health, and why those plans often fail to materialize. A person may develop a p

High profile endorsement for Dr. David Moher’s clinical trial reporting guideline


Writing in the journal Nature, two leaders of the U.S. National Institutes of Health (NIH) have commended the clinical trials community for taking “important steps towards adopting standard reporting elements” developed by Dr. David Moher and his col

Girls more likely to visit hospital after MMR vaccine


Girls have an increased likelihood of reacting to the one-year MMR vaccine than boys, according to a large, Ontario population-based study by led Dr. Kumanan Wilson and published in Vaccine. The MMR vaccine is an immunization against measles, mumps and rubella that is typically given at 12 months of age. The findings suggest that there may be important physiological differences between boys and girls that cause different responses to the measles virus and measles-containing vaccines. See media release for details. Funders: Institute for Clinical Evaluative Sciences (ICES), Ontario Ministry of Health and Long-Term Care About the Ottawa Hospital Research Institute The Ottawa Hospital Research Institute (OHRI) is the research arm of The Ottawa Hospital and is an affiliated institute of the University of Ottawa, closely associated with the university’s Faculties of Medicine and Health Sciences. OHRI includes more than 1,700 scientists, clinical investigators, graduate students, pos

Everyone in health care uses the best evidence, right?


Sadly, no. In order to tackle the vexing challenge of research-use in the clinical setting, Dr. Janet Squires has been awarded a highly competitive New Investigator Award from the Canadian Institutes of Health Research. Dr. Squires will synthesize ex

5 ways to increase value and reduce waste in research


Dr. David Moher played a key role in a new Lancet series on increasing value and reducing waste in biomedical research. The series documents waste in research from five principal sources, ranging from waste in deciding what research to do, through to waste because of unusable reports of research. Dr. Moher is a co-author on two of the five papers in the series. About the Ottawa Hospital Research Institute The Ottawa Hospital Research Institute (OHRI) is the research arm of The Ottawa Hospital and is an affiliated institute of the University of Ottawa, closely associated with the university’s Faculties of Medicine and Health Sciences. OHRI includes more than 1,700 scientists, clinical investigators, graduate students, postdoctoral fellows and staff conducting research to improve the understanding, prevention, diagnosis and treatment of human disease. Media contact Jennifer Ganton Director, Communications and Public Relations Ottawa Hospital Research Institute 613-798-5555 x

Birth order matters: Eldest more likely to visit hospital after vaccinations


Ottawa and Toronto, Canada — First-born children have a higher incidence of post-vaccination emergency room (ER) visits and admissions than later-born children for vaccinations up to 12 months of age, says a new Ontario study from researchers at the

Cochrane Canada receives 2013 CIHR Knowledge Translation Award: Ottawa-based Centre puts the best knowledge in the hands of health care providers professionals and patients as part of international collaboration


The Canadian Institutes of Health Research (CIHR) is pleased to announce that Cochrane Canada is the recipient of the 2013 CIHR Knowledge Translation Award. The Canadian Cochrane Centre Director and researcher at the University of Ottawa and the Otta

Research could solve prostate cancer controversy


New research led by Dr. Rodney Breau is shedding light on a major controversy around how best to treat prostate cancer patients who have had their prostates removed. While some studies suggest that no follow-up treatment is required, others have sugg

Outstanding research on display at the Ottawa Hospital Research Institute’s 13th annual Research Day


The Ottawa Hospital Research Institute’s 13th Annual Research Day was a great success, with more than 350 attendees packing the St. Elias Centre to capacity. Designed to highlight and celebrate the outstanding work of trainees, as well as promote sci

First patient treated in groundbreaking stem cell therapy trial for heart attack


Ottawa, Canada — Canadian researchers have treated the first patient in a world-first clinical trial using genetically enhanced stem cells to repair damaged heart muscle after a major heart attack. The formal name of the trial is ENACT-AMI, which sta

Flu vaccine safe for children with IBD: Study


TORONTO and OTTAWA – Influenza immunization rates in children with inflammatory bowel disease (IBD) are low despite its safety according to a new study by researchers at the Institute for Clinical Evaluative Sciences (ICES), Children’s Hospital of Ea

International Ethics Guidelines for Cluster Randomized Trials Published—A World First


In this month’s PLoS Medicine, Charles Weijer of the Rotman Institute of Philosophy, Jeremy Grimshaw and Monica Taljaard of the Ottawa Hospital Research Institute and colleagues publish the Ottawa Statement on the Ethical Design and Conduct of Cluste

Fresh blood not better, clinical trial shows


Ottawa — In a finding that runs counter to commonly held beliefs about fresh being better, a clinical trial published today by the Journal of the American Medical Association shows that acutely ill premature babies who received fresher blood did not

Unhealthy habits are costing Ontarians 7.5 years of life: Study examines impact of smoking, alcohol, diet, physical activity and stress


Unhealthy habits are costing Ontarians 7.5 years of life. However, by reducing five unhealthy behaviours Ontarians could become the healthiest people in the entire country. New research from the Institute for Clinical Evaluative Sciences (ICES), Publ

Ottawa researcher helps launch world’s first open access journal for systematic reviews


Clinical trials often have inconclusive findings and sometimes produce results that are contradicted by subsequent studies. Those that evaluate the effectiveness of an intervention thoroughly, may lack the same rigor when reporting on associated adve

Ottawa research could reduce use of unnecessary medications in people with HIV


New research led by Dr. Jonathan Angel could spare many people with HIV from having to take unnecessary antibiotics associated with major side effects. A systematic review by Dr. Angel and his colleagues showed that when viral levels are suppressed,

Ottawa Hospital Research Institute and CHEO Research Institute open new research centre dedicated to improving health and patient care


Medical research often happens in small steps, but a new facility at The Ottawa Hospital is designed to enable researchers to answer the big questions that can truly change medical practice and make a difference for patients. Called the Centre for Pr

Study finds serious reactions to MMR vaccine are rare


New research led by Dr. Kumanan Wilson shows that children are more likely to show up in emergency rooms one to two weeks after getting their first measles, mumps and rubella vaccine shot, however in the vast majority of cases, these reactions are se

International meeting advances the development of ethical guidelines for clinical trials


Dr. Monica Taljaard recently hosted an international meeting on the ethics of cluster-randomized clinical trials, which compare different treatments by randomly assigning some regions (or hospitals) to provide one treatment while the others provide a

New research shows most urgent hospital readmissions are hard to avoid


New research led by Dr. Carl van Walraven suggests that contrary to popular belief, most urgent hospital readmissions can’t be blamed on medical errors or gaps in care. After analyzing records from nearly 5,000 patients from 11 Ontario hospitals, Dr.

Ottawa Hospital researchers awarded $4.8M from Ontario Research Fund to advance regenerative medicine and patient safety


Two research teams affiliated with the Ottawa Hospital Research Institute (OHRI), The Ottawa Hospital (TOH) and the University of Ottawa (uOttawa) have been awarded major new grants through the Ontario Research Fund – Research Excellence competition.

New research assesses compliance with ethical guidelines for clinical trials


A new study led by Dr. Monica Taljaard suggests that researchers around the world are getting better at following certain ethical guidelines for clinical trials, but more work still needs to be done. Dr. Taljaard and her colleagues found that ethical

Ottawa medical researchers awarded close to $20M by CIHR


Researchers affiliated with the University of Ottawa’s Faculty of Medicine, the Ottawa Hospital Research Institute (OHRI), the University of Ottawa Heart Institute (UOHI) and the CHEO Research Institute (CHEO RI) are about to embark on exciting new r

Making our best health care evidence even better


An international group is encouraging health researchers around the world to publicly register and provide details about planned systematic reviews in an effort to improve health decision-making and the systematic review process. Systematic revie

New research shows cystic fibrosis patients in Ontario are at risk for infection with dangerous strain of bacteria


New research published in the Journal of the American Medical Association (JAMA) suggests that 15 per cent of Ontario Cystic Fibrosis (CF) patients are infected with a strain of bacteria that makes them twice as likely to die or require a lung transplant...

Ottawa researcher elected Co-Chair of Cochrane Collaboration


Dr. Jeremy Grimshaw has been elected Co-Chair of the Cochrane Collaboration, a highly prestigious international research network that helps people make informed healthcare decision. The announcement was made on October 28, 2010, after more than 400

Outstanding researchers at uOttawa and OHRI to receive significant funding


The Ontario Ministry of Research and Innovation today announced $3.6 million dollars in funding to support the outstanding research being conducted by professors and students from the University of Ottawa and the Ottawa Hospital Research Institute. Eight research projects, in areas such as health and medicine, nanophotonics, physics and visual arts...

Cochrane Canada receives $9.6M from CIHR


The Canadian Institutes of Health Research recently announced $9.6 million in funding over the next five years to Cochrane Canada to help fulfill its mission of cultivating evidence-based health decision-making by promoting the use and accessibility of Cochrane Reviews. Cochrane Canada is led by Dr. Jeremy Grimshaw at OHRI...

Nine leading medical journals publish clinical trial reporting guidelines developed by Ottawa researcher


New guidance to improve the reporting of trial findings is published simultaneously today by nine leading medical journals. Full and transparent reporting of trials is crucial to ensure that decisions about health care are based on the best available evidence...

Ottawa researchers develop guidelines for better reporting of health research


A paper published in this week's issue of PLoS Medicine provides a substantial new resource for developing guidelines for reporting health research. The paper was written by Dr. David Moher of the Ottawa Hospital Research Institute and the University of Ottawa, along with colleagues from the U.S. and the U.K...

OHRI awarded $7.8M from Canadian Institutes of Health Research


Fifteen OHRI / uOttawa scientists have been awarded grants worth a total of $7.8M from the Canadian Institutes of Health Research (CIHR). This funding will help the researchers develop better therapies, answer important health questions and make our health care system more effective and efficient...

Ottawa Hospital Gala raises impressive amount for groundbreaking research


The 2009 Ottawa Hospital Gala was a tremendous success raising $120,000 for the Ottawa Hospital Research Institute. Drs. Jeremy Grimshaw, Johné Liu and Mitchell Baldwin were honoured for their research in knowledge translation, cell biology and brain cancer, respectively...

Improving care for people with neck injuries: Ottawa hospital-led study paves the way for worldwide adoption of Canadian C-Spine Rule


A 12-hospital clinical trial has shown that active promotion of the Canadian C-Spine Rule in emergency departments can significantly reduce the use of unnecessary neck x-rays without compromising the detection of serious neck injuries. The study is p

Ottawa rehabilitation researchers find simulated space travel increases bone marrow fat


As a specialist at The Ottawa Hospital Rehabilitation Centre, Dr. Guy Trudel has always been interested in improving how patients recover from long term injuries and immobility, so when an opportunity arose to study a similar problem in the unique context of space...

OHRI / uOttawa research shows heart rate monitors could help detect sepsis earlier


A new research study led by Dr. Andrew Seely and Dr. Saif Ahmad shows that a simple heart rate monitor may be able to detect the first signs of sepsis, a potentially lethal blood infection, almost a day and a half before traditional methods. The researchers developed a sophisticated mathematical algorithm to analyze variation in heart rate and detect patterns...

Five top medical journals publish research guidelines developed in Ottawa


An international group led by Dr. David Moher of the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa has today released guidelines to improve how highly influential reviews of medical and health research are reported. The guide

Study points to need for more training in clinical trial design in China


A survey of more than 3,000 randomized clinical trials published in Chinese journals suggests that less than 10 per cent are actually randomized according to accepted guidelines. The survey, published in BioMed Central’s open access journal, Trials, was led by Dr. David Moher of Ottawa, Canada and Dr. Taixiang Wu of Sichuan, China.

OHRI awarded $12M for national network to translate clinical research results into better health


The Ottawa Hospital Research Institute (OHRI), an affiliated institute of the University of Ottawa, has been awarded $12.2M to lead a groundbreaking new national research network called Knowledge Translation Canada (KT Canada). The network will addre

Free access to Cochrane Library health information for all Canadians


The Canadian Cochrane Network and Centre, led by OHRI scientist Dr. Jeremy Grimshaw, announced today that everyone in Canada with access to the Internet will be able to view the full content of The Cochrane Library, an online resource that provides evaluations on health treatments...

Genes and disease: OHRI scientists contribute to guidelines for reporting genetic associations


Several high-profile medical journals are publishing the results of a recent initiative designed to enhance the transparency of reporting in genetic-association studies — performed to determine whether a genetic variant is associated with a disease or trait.

Dr. Jeremy Grimshaw and Dr. Dean Fergusson recognized at OCRI Life Sciences Achievement Awards Dinner


Two OHRI Scientists were recognized at the OCRI Life Sciences Achievement Awards Dinner. Dr. Dean Fergusson received the Dr. Michael Smith Promising Scientist Award for his work in transfusion medicine while Dr. Jeremy Grimshaw received the Research

Aprotinin associated with increased risk of death: Canadian trial published in NEJM compares three drugs routinely used to prevent blood loss during heart surgery


Aprotinin is associated with a 50 per cent increase in the relative risk of death, according to a major Canadian clinical trial comparing three drugs routinely used to prevent blood loss during heart surgery. The trial, published in the New England Journal of Medicine, shows that approximately six per cent of patients who received aprotinin died within 30 days of surgery compared to four per cent of patients who received tranexamic acid or aminocaproic acid.