Jerry Radziuk, PhD, MD
jradziuk@ohri.ca
Senior Scientist, Chronic Disease, Ottawa Hospital Research Institute
Director, Diabetes and Metabolism Research Unit, Director, Clinical Investigation Unit, Division of Endocrinology and Metabolism, The Ottawa HospitalProfessor, Department of Medicine and Physiology, University of Ottawa
Research Interests
Metabolism: glycogen; pathways and control of glycogen synthesis; intermediary metabolism; gluconeogenesis; substrates for gluconeogenesis; regulation of carbohydrate metabolism; intestinal glucose absorption and disposition; gut hormones.
Insulin: systemic kinetics; secretion (in vivo); insulin removal and degradation; therapeutics; insulin analogs; insulin action.
General: The above issues in diabetes, cirrhosis, exercise. Pharmacokinetics; bioavailability, mathematical models.
Major Research Activities
Dr. Radziuk's long-term research interests have focused on the pathogenesis of Type II (non-insulin dependent) diabetes mellitus, in particular insulin resistance. Ongoing research is on carbohydrate in intermediary metabolism and insulin dynamics, using in vivo experimental models and applying the technology of mathematical modelling.
Dr. Radziuk has extended his research activities to look at exercise and metabolism. He uses three animal models: the swimming rat, the running rat and the running dog. Exercise is a hypoinsulinemic state and thus exercise and recovery from exercise are ideal situations in which to study muscle metabolism, in particular glycogen and the dynamics of insulin.
He is also investigating the interrelationships of glucose and lactate in the control of glycogen synthesis in the perfused rat in order to elaborate in more detail the specific roles of lactate in the control of glycogen metabolism.
Another area of study is the liver and insulin action: a surgical liver bypass model was developed for these experiments which have shown that physically bypassing the liver decreases peripheral insulin sensitivity to less than 50% of normal. The implications of this result in therapy, physiology, transplantation as well as the pathogenesis of insulin resistance are being explored.
The role of the gut in modulating metabolism and its regulation by pancreatic hormones is being assessed using a variety of gut hormones such as galanin and glucagon-like peptide-1.
Recent Publications (provided by The Ottawa Hospital Library Database)
Xu J;Zhang L;Chou A;Allaby T;Belanger G;Radziuk J;Jasmin BJ;Miki T;Seino S;Renaud JM;, (2008 Feb), KATP channel-deficient pancreatic beta-cells are streptozotocin resistant because of lower GLUT2 activity, Am J Physiol Endocrinol Metab, Vol.294, Issue 2, E326-E335 -> view abstract
Radziuk J;Pye S;, (2006 Jul), Diurnal rhythm in endogenous glucose production is a major contributor to fasting hyperglycaemia in type 2 diabetes. Suprachiasmatic deficit or limit cycle behaviour?19, Diabetologia, Vol.49, Issue 7, 1619-1628
Radziuk J;Pye S;, (2004 Sep), Endogenous glucose production in type 2 diabetes: basal and postprandial. Role of diurnal rhythms. [Review] [62 refs], Journal of Investigative Medicine, Vol.52, Issue 6, 379-388 -> view abstract
Radziuk J;, (2004 Sep), Glucose production in health and type 2 diabetes: measurement, regulation, and molecular basis. An overview, Journal of Investigative Medicine, Vol.52, Issue 6, 364-365
Radziuk J;Pye S;, (2003 Sep), Tracer-determined glucose fluxes in health and type 2 diabetes: basal conditions. [Review] [77 refs], Best Practice & Research Clinical Endocrinology & Metabolism , Vol.17, Issue 3, 323-342 -> view abstract
Barthelmebs M;Wiernsperger N;Krieger JP;Rapin JR;Radziuk J;Grima M;Imbs JI;, (2003 Apr), Mild acute renal failure potentiates metformin accumulation in the diabetic rat kidney without further impairment of renal function, Diabetes & Metabolism, Vol.29, Issue 2 Pt 1, 163-170 -> view abstract
Radziuk J;Pye S;, (2002 Aug), Quantitation of basal endogenous glucose production in Type II diabetes: importance of the volume of distribution. [Review] [165 refs], Diabetologia, Vol.45, Issue 8, 1053-1084 -> view abstract
Radziuk J;Pye S;, (2001 Jul), Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis. [Review] [244 refs], Diabetes/Metabolism Research Reviews, Vol.17, Issue 4, 250-272 -> view abstract
Radziuk J;Pye S;, (2001 Aug), Production and metabolic clearance of glucose under basal conditions in Type II (non-insulin-dependent) diabetes mellitus, Diabetologia, Vol.44, Issue 8, 983-991 -> view abstract
Radziuk J;, (2000 Dec), Insulin sensitivity and its measurement: structural commonalities among the methods. [Review] [48 refs], Journal of Clinical Endocrinology & Metabolism, Vol.85, Issue 12, 4426-4433 -> view abstract
Note: This is not a complete list of publications. More publications may be available in The Ottawa Hospital Library database and Pubmed (search by last name and initials).
