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Rhian M Touyz MD, PhD.
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Senior Scientist
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Chronic Disease
, Ottawa Hospital Research Institute
Physician, Division of Nephrology, The Ottawa Hospital
Professor, Department of Medicine, University of Ottawa
Canada Research Chair in Hypertension
Biographical sketch
Dr Touyz, MBBCh, MSc(Med), PhD, is the Canada Research Chair in Hypertension at the Kidney Research Centre, Ottawa Hospital Research Institute/Univ of Ottawa. She is a Senior Scientist at the OHRI and physician in the Division of nephrology. Dr Touyz received her medical training and subsequent degrees from the University of the Witwatersrand, Johannesburg, South Africa. She has received numerous academic and research awards, including the Young Investigator Awards from the American Society of Hypertension, the Canadian Society of Hypertension and the Quebec Society of Hypertension as well as being a finalist for the Irving H Page Award, Atherosclerosis Thrombosis and Vascular Biology from the American Heart Association. Dr Touyz has been awarded the 2005 Dahl Lecture Award by the American Heart Association and the 2006 Grace A Goldsmith Award, American Society of Nutrition in recognition of her contributions to hypertension research. Dr Touyz is on the executive of the Canadian Hypertension Education Program (CHEP), she co-chairs the Recommendations Task Force of CHEP and she is the President of the Canadian Hypertension Society. She is the Scientific Officer of the Cardiovascular committees at the Canadian Institutes of Health Research and the Heart and Stroke Foundation of Canada and she is a member of the Microcirculation and Hypertension Review panel of the National Institutes of Health in the USA. She is funded by grants from the Heart and Stroke Foundation of Canada and the Canadian Institutes of Health Research. She is the Associate Editor of the journals Clinical Science and the Journal of the American Society of Hypertension and she is on the on the editorial board of Hypertension, Journal of Hypertension, American Journal of Physiology, Magnesium, Current Hypertension Reviews, Circulation Research and Current Opinion in Nephrology and Hypertension. Dr Touyz has published over 200 original papers and more than 30 review articles. Her main focus of research relates to molecular and cellular mechanisms of hypertension. Her areas of study include clinical and experimental hypertension, hypertension in renal disease, signal transduction, oxidative stress, ion transport, vascular remodeling and insulin resistance and diabetes. She has a particular interest in translational research.
Most Recent Publications (provided by The Ottawa Hospital Library Database)
Yogi A;Callera GE;Hipolito UV;Silva CR;Touyz RM;Tirapelli CR;, (2010), Ethanol-induced vasoconstriction is mediated via redox-sensitive cyclo-oxygenase-dependent mechanisms, Clin Sci (Lond), Vol.118, Issue 11, 657-668 -> view abstract
Fu A;Ng AC;Depatie C;Wijesekara N;He Y;Wang GS;Bardeesy N;Scott FW;Touyz RM;Wheeler MB;Screaton RA;, (2009 Oct), Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice, Cell Metabolism, Vol.10, Issue 4, 285-295 -> view abstract
Sedeek M;Hebert RL;Kennedy CR;Burns KD;Touyz RM;, (2009 Mar), Molecular mechanisms of hypertension: role of Nox family NADPH oxidases. [Review] [80 refs], Current Opinion in Nephrology & Hypertension, Vol.18, Issue 2, 122-127 -> view abstract
Touyz RM;Callera GE;, (2009 Jan 2), A new look at the eye: aldosterone and mineralocorticoid receptors as novel targets in retinal vasculopathy.[comment], Circulation Research, Vol.104, Issue 1, 9-11
Callera GE;He Y;Yogi A;Montezano AC;Paravicini T;Yao G;Touyz RM;, (2009 Jan), Regulation of the novel Mg2+ transporter transient receptor potential melastatin 7 (TRPM7) cation channel by bradykinin in vascular smooth muscle cells, J Hypertens, Vol.27, Issue 1, 155-166 -> view abstract
Callera GE;He Y;Yogi A;Montezano AC;Paravicini T;Yao G;Touyz RM;, (2009 Jan), Regulation of the novel Mg2+ transporter transient receptor potential melastatin 7 (TRPM7) cation channel by bradykinin in vascular smooth muscle cells, Journal of Hypertension, Vol.27, Issue 1, 155-166 -> view abstract
Touyz RM;Montezano AC;, (2009 Feb 1), Vascular smooth muscle cells sense calcium: a new paradigm in vascular calcification, Cardiovasc Res, Vol.81, Issue 2, 237-239
Yogi A;Callera GE;Tostes R;Touyz RM;, (2009 Feb), Bradykinin regulates calpain and proinflammatory signaling through TRPM7-sensitive pathways in vascular smooth muscle cells, American Journal of Physiology - Regulatory Integrative & Comparative Physiology, Vol.296, Issue 2, R201 -> view abstract
Paravicini TM;Yogi A;Mazur A;Touyz RM;, (2009 Feb), Dysregulation of vascular TRPM7 and annexin-1 is associated with endothelial dysfunction in inherited hypomagnesemia, Hypertension, Vol.53, Issue 2, 423-429 -> view abstract
Takami K;Touyz LZ;Touyz RM;, (2009 Dec 12), Liquorice alert, Br Dent J, Vol.207, Issue 11, 519
Additional Publications (2008)
Touyz RM. Apocynin, NADPH oxidase and vascular cells - a complex matter. Hypertension 2008;51:172-174.
Yogi A, Mercure C, Touyz J, Callera GE, Montezano AC, Aranha AB, Tostes RC, Reudelhuber T, Touyz RM. Renal redox-sensitive signaling, but not blood pressure, is attenuated by Nox1 knockout in angiotensin II-dependent chronic hypertension. Hypertension. 2008;51(2):500-6.
Touyz RM. Transient Receptor Potential Melastatin 6 and 7 Channels, Magnesium Transport and Vascular Biology: Implications in Hypertension.
Am J Physiol Heart Circ Physiol. 2008 Jan 11; [Epub ahead of print]
Paravicinin T, Touyz RM. NADPH oxidases, reactive oxygen species and hypertension - clinical implications and therapeutic possibilities. Diabetes Care 2008;31:S170-S180
Note: This is not a complete list of publications. More publications may be available in The Ottawa Hospital Library database and Pubmed (search by last name and initials).
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